Access to a running wheel inhibits the acquisition of cocaine self-administration.
Access to a running wheel inhibits the acquisition of cocaine self-administration.
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DOI：
10.1016/j.pbb.2011.08.025
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Pitts EG
中科院分区：
文献类型：
--
作者：
Smith MA;Pitts EG
体力活动减少可卡因自我管理在实验室动物，并与药物滥用治疗计划的积极成果;然而，鲜为人知的是，它的有效性，防止建立药物使用的规律在药物幼稚的个人。本研究的目的是检查的影响，获得一个运行轮可卡因自我管理的实验幼稚大鼠。在断奶时获得雄性Long-Evans大鼠，并在到达后立即分配至久坐（无轮子）或运动（使用轮子）条件。六周后，将大鼠手术植入静脉内导管，并置于操作性调节室中，每天2小时，连续15天。每一届会议开始与非偶然的启动注入可卡因，随后由一个自由操作的时期，其中每一个反应的主动杠杆上产生了一个注入可卡因的固定比例（FR 1）的时间表的强化。对于第1-5天，0.25 mg/kg/输注可卡因增强了反应;对于第6- 1 - 5天，0.75 mg/kg/输注可卡因增强了反应。此外，在第11-15天期间，所有大鼠的热量限制为其自由进食体重的85%至95%。与久坐不动的大鼠相比，运动大鼠在15天的行为测试中以明显较慢的速度获得可卡因自我给药，并发出明显较少的主动杠杆按压。这些数据表明，获得一个运行轮抑制可卡因自我管理的收购，和体力活动可能是一种有效的干预药物滥用预防计划。
Physical activity decreases cocaine self-administration in laboratory animals and is associated with positive outcomes in substance abuse treatment programs; however, less is known about its efficacy in preventing the establishment of regular patterns of substance use in drug-naive individuals. The purpose of the present study was to examine the effects of access to a running wheel on the acquisition of cocaine self-administration in experimentally naive rats. Male, Long-Evans rats were obtained at weaning and assigned to sedentary (no wheel) or exercising (access to wheel) conditions immediately upon arrival. After six weeks, rats were surgically implanted with intravenous catheters and placed in operant conditioning chambers for 2 hr/day for 15 consecutive days. Each session began with a noncontingent priming infusion of cocaine, followed by a free-operant period in which each response on the active lever produced an infusion of cocaine on a fixed ratio (FR1) schedule of reinforcement. For days 1–5, responding was reinforced with 0.25 mg/kg/infusion cocaine; for days 6–15, responding was reinforced with 0.75 mg/kg/infusion cocaine. In addition, all rats were calorically restricted during days 11–15 to 85% to 95% of their free-feeding body weight. Compared to sedentary rats, exercising rats acquired cocaine self-administration at a significantly slower rate and emitted significantly fewer active lever presses during the 15 days of behavioral testing. These data indicate that access to a running wheel inhibits the acquisition of cocaine self-administration, and that physical activity may be an effective intervention in substance abuse prevention programs.
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