Light acts through melanopsin to alter retinal waves and segregation of retinogeniculate afferents.

Light acts through melanopsin to alter retinal waves and segregation of retinogeniculate afferents.
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DOI:
10.1038/nn.2845
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发表时间:
2011-06-05
影响因子:
25
通讯作者:
Berson, David M.
Berson, David M.
中科院分区:
医学1区
文献类型:
--
作者:
Renna, Jordan M.;Weng, Shijun;Berson, David M.

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出生后早期小鼠视网膜上的相关活动波促进离视网膜投射的分离和细化。这个过程被认为是自发的,不受视觉经验的影响。然而,我们发现,光抑制了波期间的尖峰,并增强了视网膜神经传入的分离,并且它通过激活表达黑视素的内在光敏视网膜神经节细胞来实现。
Waves of correlated activity sweeping across the early postnatal mouse retina promote the segregation and refinement of retinofugal projections. This process has been thought to be spontaneous and unaffected by visual experience. We found, however, that light prolongs spiking during the waves and enhances the segregation of retinogeniculate afferents, and that it did so by activating melanopsin-expressing, intrinsically photosensitive retinal ganglion cells.
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