Unpacking the intricacies of Rickettsia-vector interactions.

Unpacking the intricacies of Rickettsia-vector interactions.
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DOI:
10.1016/j.pt.2021.05.008
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发表时间:
2021-08
影响因子:
9.6
通讯作者:
Macaluso KR
Macaluso KR
中科院分区:
医学1区
文献类型:
--
作者:
Laukaitis HJ;Macaluso KR

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Although Rickettsia species are molecularly detected among a wide range of arthropods, vector competence becomes an imperative aspect of understanding the eco-epidemiology of these vector-borne diseases. The synergy between vector homeostasis and rickettsial invasion, replication, and release initiated within hours (insects) and days (ticks) permits successful transmission of rickettsiae. Uncovering the molecular interplay between rickettsiae and their vectors necessitates examining the multi-faceted nature of rickettsial virulence and vector infection tolerance. Here, we highlight the biological differences between tick- and insect-borne rickettsiae and the factors facilitating the incidence of rickettsioses. Untangling the complex relationship between rickettsial genetics, vector biology, and microbial interactions is crucial in understanding the intricate association between rickettsiae and their vectors.
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