LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer.
LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer.
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LncRNA OIP5-AS1 通过 miR-124-5p/IDH2/HIF-1α 通路调节宫颈癌中的 Warburg 效应
DOI：
10.3389/fcell.2021.655018
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发表时间：
2021
影响因子：
5.5
通讯作者：
Han L
中科院分区：
文献类型：
--
作者：
Li L;Ma Y;Maerkeya K;Reyanguly D;Han L
缺氧重编程糖代谢影响肿瘤细胞的瓦尔堡效应，但其机制尚不清楚。长链非编码RNA（Long-chain non-coding RNA，lncRNA）参与了肿瘤细胞在缺氧条件下的瓦尔堡效应。在此，我们发现lncRNA OIP 5-AS 1在宫颈癌组织中上调，并预测宫颈癌患者的5年总生存率较差，并且它在体外和体内促进宫颈癌细胞的细胞增殖。此外，OIP 5-AS 1是一种低氧响应性lncRNA，并且对于IDH 2或低氧诱导因子-1 α（HIF-1α）依赖的低氧增强糖酵解是必需的。在宫颈癌细胞中，OIP 5-AS 1通过抑制miR-124- 5 p促进IDH 2的表达，IDH 2通过调节HIF-1α的表达促进宫颈缺氧条件下的瓦尔堡效应。总之，缺氧诱导的OIP 5-AS 1通过miR-124- 5 p/IDH 2/HIF-1α途径促进宫颈癌中的瓦尔堡效应。
Hypoxia reprogrammed glucose metabolism affects the Warburg effect of tumor cells, but the mechanism is still unclear. Long-chain non-coding RNA (lncRNA) has been found by many studies to be involved in the Warburg effect of tumor cells under hypoxic condition. Herein, we find that lncRNA OIP5-AS1 is up-regulated in cervical cancer tissues and predicts poor 5-years overall survival in cervical cancer patients, and it promotes cell proliferation of cervical cancer cells in vitro and in vivo. Moreover, OIP5-AS1 is a hypoxia-responsive lncRNA and is essential for hypoxia-enhanced glycolysis which is IDH2 or hypoxia inducible factor-1α (HIF-1α) dependent. In cervical cancer cells, OIP5-AS1 promotes IDH2 expression by inhibiting miR-124-5p, and IDH2 promotes the Warburg effect of cervical under hypoxic condition through regulating HIF-1α expression. In conclusion, hypoxia induced OIP5-AS1 promotes the Warburg effect through miR-124-5p/IDH2/HIF-1α pathway in cervical cancer.
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DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
影响因子：
13.8
作者：
Liberti MV;Locasale JW
通讯作者：
Locasale JW
影响因子：
16.2
作者：
Feng, Rui-Mei;Zong, Yi-Nan;Xu, Rui-Hua
通讯作者：
Xu, Rui-Hua
影响因子：
8.8
作者：
Miska, Jason;Lee-Chang, Catalina;Lesniak, Maciej S.
通讯作者：
Lesniak, Maciej S.
影响因子：
16.6
作者：
Oh, Eun-Taex;Kim, Jung-whan;Kim, Joon Mee;Kim, Soo Jung;Lee, Jae-Seon;Hong, Soon-Sun;Goodwin, Justin;Ruthenborg, Robin J.;Jung, Myung Gu;Lee, Hae-June;Lee, Chul-Ho;Park, Eun Sung;Kim, Chulhee;Park, Heon Joo
通讯作者：
Park, Heon Joo