Transcriptional regulation of mammalian selenoprotein expression.
Transcriptional regulation of mammalian selenoprotein expression.
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DOI：
10.1016/j.bbagen.2009.05.012
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Berry MJ
中科院分区：
文献类型：
--
作者：
Stoytcheva ZR;Berry MJ
硒蛋白含有第21个氨基酸，硒代半胱氨酸，并参与细胞防御氧化损伤，重要的代谢和发育途径，以及对环境挑战的反应。阐明硒蛋白在转录水平上的表达调控机制是理解这些机制如何响应不断变化的环境的关键。本文综述了已发表的硒蛋白基因的转录调控研究，主要集中在基因的编码蛋白质的功能至少部分了解。其次是硒蛋白基因中预测的调控元件的计算机分析，包括上述类别中的那些以及功能未知的基因。我们的研究结果揭示了许多硒蛋白基因共同的调控途径，包括几个参与应激反应。此外，组织特异性调节因子参与调节许多硒蛋白基因。这些研究为硒蛋白基因如何应对环境和其他挑战提供了新的见解，以及这些蛋白质在允许细胞适应这些变化方面所发挥的作用。阐明影响硒蛋白表达的调控机制对于理解它们在人类疾病中的作用以及开发诊断和潜在治疗方法来解决该基因家族成员的失调是至关重要的。
Selenoproteins contain the twenty-first amino acid, selenocysteine, and are involved in cellular defenses against oxidative damage, important metabolic and developmental pathways, and responses to environmental challenges. Elucidating the mechanisms regulating selenoprotein expression at the transcriptional level is key to understanding how these mechanisms are called into play to respond to the changing environment. This review summarizes published studies on transcriptional regulation of selenoprotein genes, focused primarily on genes whose encoded protein functions are at least partially understood. This is followed by in silico analysis of predicted regulatory elements in selenoprotein genes, including those in the aforementioned category as well as the genes whose functions are not known. Our findings reveal regulatory pathways common to many selenoprotein genes, including several involved in stress-responses. In addition, tissue-specific regulatory factors are implicated in regulating many selenoprotein genes. These studies provide new insights into how selenoprotein genes respond to environmental and other challenges, and the roles these proteins play in allowing cells to adapt to these changes. Elucidating the regulatory mechanisms affecting selenoprotein expression is essential for understanding their roles in human diseases, and for developing diagnostic and potential therapeutic approaches to address dysregulation of members of this gene family.
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