AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex.
AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex.
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DOI：
10.1016/j.semcdb.2011.06.007
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发表时间：
2011-07
影响因子：
7.3
通讯作者：
Kirkwood, Alfredo
中科院分区：
文献类型：
--
作者：
Lee, Hey-Kyoung;Kirkwood, Alfredo
布利斯和L在兔海马齿状回中发现了长时程增强，为研究脑中依赖活动的长期突触修饰开辟了一个全新的领域。从那时起，海马区突触就成为研究不同形式突触可塑性机制的关键模型系统。至少对于突触后形式的LTP和长期抑郁(LTD)来说，AMPA受体(AMPAR)的调节已经成为一个关键机制。虽然在海马区突触中发现的许多突触可塑性机制适用于不同大脑区域的突触，但往往揭示所研究脑区特定功能需求的机制存在差异。在这里，我们将回顾AMPAR在海马区和大脑皮层突触可塑性中的调控。这篇综述的主要焦点将放在突触后可塑性的形式影响AMPAR的调节，以海马CA1和初级感觉皮质为例。通过比较，我们将突出这两个突触之间的关键相似之处和功能差异。
Discovery of long-term potentiation (LTP) in the dentate gyrus of the rabbit hippocampus by Bliss and Lømo opened up a whole new field to study activity-dependent long-term synaptic modifications in the brain. Since then hippocampal synapses have been a key model system to study the mechanisms of different forms of synaptic plasticity. At least for the postsynaptic forms of LTP and long-term depression (LTD), regulation of AMPA receptors (AMPARs) has emerged as a key mechanism. While many of the synaptic plasticity mechanisms uncovered in at the hippocampal synapses apply to synapses across diverse brain regions, there are differences in the mechanisms that often reveal the specific functional requirements of the brain area under study. Here we will review AMPAR regulation underlying synaptic plasticity in hippocampus and neocortex. The main focus of this review will be placed on postsynaptic forms of synaptic plasticity that impinge on the regulation of AMPARs using hippocampal CA1 and primary sensory cortices as examples. And through the comparison, we will highlight the key similarities and functional differences between the two synapses.
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影响因子：
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