Microbial Stimulation Reverses the Age-Related Decline in M Cells in Aged Mice
Microbial Stimulation Reverses the Age-Related Decline in M Cells in Aged Mice
复制标题
微生物刺激可逆转老年小鼠 M 细胞与年龄相关的下降
DOI：
10.1101/2020.02.17.943514
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Donaldson D
中科院分区：
文献类型：
--
作者：
Donaldson D
衰老对免疫系统有深远的影响，称为免疫衰老，导致感染的发病率和严重程度增加，疫苗接种的效力降低。我们以前表明，免疫监视在肠道，主要是通过抗原采样M细胞的滤泡相关上皮（FAE）的派尔集合淋巴结，在老化过程中由于M细胞功能成熟的下降而受到损害。肠道微生物群也随着年龄的增长而发生显著变化，但这是否会影响M细胞的成熟尚不清楚。我们表明，住房的老年小鼠使用的床上用品从年轻的小鼠，或治疗与细菌鞭毛蛋白，每一个都足以提高功能成熟的M细胞在派尔集合淋巴结。了解肠道微生物群对M细胞影响的机制有可能找到新的方法来提高老年人口服疫苗的功效。
Aging has a profound effect on the immune system, termed immunosenescence, resulting in increased incidence and severity of infections and decreased efficacy of vaccinations. We previously showed that immunosurveillance in the intestine, achieved primarily through antigen sampling M cells in the follicle associated epithelium (FAE) of Peyer's patches, was compromised during aging due to a decline in M cell functional maturation. The intestinal microbiota also changes significantly with age, but whether this affects M cell maturation was not known. We show that housing of aged mice on used bedding from young mice, or treatment with bacterial flagellin, were each sufficient to enhance the functional maturation of M cells in Peyer's patches. An understanding of the mechanisms underlying the influence of the intestinal microbiota on M cells has the potential to lead to new methods to enhance the efficacy of oral vaccination in aged individuals.
登录
查看更多内容
影响因子：
30.3
作者：
Kubinak JL;Petersen C;Stephens WZ;Soto R;Bake E;O'Connell RM;Round JL
通讯作者：
Round JL
将 SPF 小鼠转移至正常动物房环境后，M 细胞数量增加。
影响因子：
6
作者：
M. Smith;P. James;D. Tivey
通讯作者：
D. Tivey
影响因子：
3.7
作者：
Elderman M;Sovran B;Hugenholtz F;Graversen K;Huijskes M;Houtsma E;Belzer C;Boekschoten M;de Vos P;Dekker J;Wells J;Faas M
通讯作者：
Faas M
影响因子：
5.3
作者：
de Lau, Wim;Kujala, Pekka;Clevers, Hans
通讯作者：
Clevers, Hans
影响因子：
4.6
作者：
Sovran, Bruno;Hugenholtz, Floor;Wells, Jerry M.
通讯作者：
Wells, Jerry M.