Beneficial effects of non-matched allogeneic cord blood mononuclear cells upon patients with idiopathic osteoporosis.
Beneficial effects of non-matched allogeneic cord blood mononuclear cells upon patients with idiopathic osteoporosis.
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非匹配同种异体脐带血单核细胞对特发性骨质疏松症患者的有益作用
DOI：
10.1186/1479-5876-10-102
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发表时间：
2012-05-21
影响因子：
7.4
通讯作者：
Pan XH
中科院分区：
文献类型：
--
作者：
Li J;Zhang L;Zhou L;Yu ZP;Qi F;Liu B;Zi SX;Li L;Li Y;Wang SB;Cui ZJ;Pan XH
免疫学论据和历史实例表明，用脐带血治疗非造血活动，如生长因子的产生和血管生成的刺激，可能不需要匹配或免疫抑制。方法对8例特发性骨质疏松患者采用不匹配的异体脐带血单核细胞间歇治疗3个月，研究血单核细胞治疗的获益性。在为期一年的研究中，收集晨禁食样本，测定尿液中1型胶原蛋白N端肽、血清骨特异性碱性磷酸酶和胰岛素样生长因子1。结果临床反应显著。与基线值相比，所有患者血清胰岛素样生长因子1在3个月时显著升高，从264.1±107.0增加到384.4±63.1 ng/mL (P= 0.002)，并有在12个月时恢复到基线值的趋势（312.9±75.5 ng/mL，P= 0.083）。血清骨特异性碱性磷酸酶和尿1型胶原N端肽在3个月（P= 0.765，P= 0.057）和12个月（P= 0.889，P= 0.122）时差异均无统计学意义。在所有腰椎患者中均观察到对骨密度的有益影响。治疗期间计算的平均骨密度（0.6811±0.1442 g/cm2）倾向于高于基线值（0.6239±0.1362 g/cm2，P< 0），百分比变化（中位数）从3个月的8.85%到1年的7.85%不等。一年后，所有的病人现在都很好。结论在特发性骨质疏松患者中，脐带血单个核细胞治疗可导致胰岛素样生长因子1水平显著升高，有利于骨密度的增加。
BackgroundImmunological arguments and historical examples have shown that treatment with cord blood for non-hematopoietic activities, such as growth factor production and stimulation of angiogenesis, may not require matching or immune suppression.MethodsTo study the benefit of blood mononuclear cell therapy, 8 patients with idiopathic osteoporosis were given intermittent treatments with non-matched allogeneic cord blood mononuclear cells for 3 months. Morning fasting samples were collected for measuring urine N telopeptide of type-1 collagen, serum bone-specific alkaline phosphatase, and insulin-like growth factor 1 during one-year study.ResultsClinical response was striking. Serum insulin-like growth factor 1 significantly increased in all patients at 3 months compared with baseline values, from 264.1 ± 107.0 to 384.4 ± 63.1 ng/mL (P= 0.002), with a tendency to return to baseline values at 12 months (312.9 ± 75.5 ng/mL,P= 0.083). In contrast, differences in serum bone-specific alkaline phosphatase and urine N telopeptide of type-1 collagen were not significant at 3 (P= 0.765,P= 0.057) or 12 months (P= 0.889,P= 0.122). A beneficial effect on bone density was observed in all patients at the lumbar spine. The mean bone mineral density calculated during therapy (0.6811 ± 0.1442 g/cm2) tended higher than baseline values (0.6239 ± 0.1362 g/cm2,P< 0), and percentage change (median) varied from 8.85% at 3 months to 7.85% at one year. All patients are now well after one year.ConclusionsThe findings indicate that for these patients with idiopathic osteoporosis, treatment with cord blood mononuclear cells led to a significant increase in insulin-like growth factor 1 levels, which favors the increase in bone mineral density.
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影响因子：
16.2
作者：
Haller MJ;Wasserfall CH;McGrail KM;Cintron M;Brusko TM;Wingard JR;Kelly SS;Shuster JJ;Atkinson MA;Schatz DA
通讯作者：
Schatz DA
影响因子：
5.2
作者：
Kong, KY;Ren, JM;Brown, RH
通讯作者：
Brown, RH
影响因子：
2.2
作者：
Clines GA
通讯作者：
Clines GA
影响因子：
4.5
作者：
Lim JJ;Jang JB;Kim JY;Moon SH;Lee CN;Lee KJ
通讯作者：
Lee KJ
DOI：
10.1089/152581603322022990
发表时间：
2003-06-01
期刊：
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
影响因子：
--
作者：
Garbuzova-Davis, S;Willing, AE;Sanberg, PR
通讯作者：
Sanberg, PR