Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview.
Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview.
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DOI：
10.1007/s12035-014-8657-1
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发表时间：
2014-10
影响因子：
5.1
通讯作者：
Heneka, Michael T.
中科院分区：
文献类型：
--
作者：
Brosseron, Frederic;Krauthausen, Marius;Kummer, Markus;Heneka, Michael T.
本文就阿尔茨海默病（AD）和轻度认知功能障碍（MCI）患者血浆、血清和脑脊液（CSF）中细胞因子及其他炎症相关蛋白水平的变化作一综述。我们回顾了1989年至2013年间发表的118篇研究文章，比较了MCI和AD患者血液或CSF中与炎症调节和信号传导相关的66种细胞因子和其他蛋白质的报告水平。几种细胞因子在与神经退行性疾病相关的（神经）炎症过程中受到明显调节。其他患者在疾病进展期间不显示血液或CSF的变化。然而，许多关于MCI或AD中细胞因子水平的报道是有争议的或不确定的，特别是那些提供经常研究的细胞因子如肿瘤坏死因子α（TNF-α）或白细胞介素-6（IL-6）的数据的报道。几种细胞因子的水平是AD中神经炎症的可能指标。其中一些可能在疾病进展期间稳定增加或在MCI向AD转化时暂时增加。此外，体液细胞因子水平升高可能与MCI转化为AD的风险增加相关。然而，研究结果相互矛盾。为了克服个体间的差异，并获得更明确的描述细胞因子的调节和功能的神经退行性疾病，高度的有条不紊的标准化和患者的集体表征，连同纵向采样多年是必不可少的。本文的在线版本（doi：10.1007/s12035-014-8657-1）包含补充材料，可供授权用户使用。
This article gives a comprehensive overview of cytokine and other inflammation associated protein levels in plasma, serum and cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). We reviewed 118 research articles published between 1989 and 2013 to compare the reported levels of 66 cytokines and other proteins related to regulation and signaling in inflammation in the blood or CSF obtained from MCI and AD patients. Several cytokines are evidently regulated in (neuro-) inflammatory processes associated with neurodegenerative disorders. Others do not display changes in the blood or CSF during disease progression. However, many reports on cytokine levels in MCI or AD are controversial or inconclusive, particularly those which provide data on frequently investigated cytokines like tumor necrosis factor alpha (TNF-α) or interleukin-6 (IL-6). The levels of several cytokines are possible indicators of neuroinflammation in AD. Some of them might increase steadily during disease progression or temporarily at the time of MCI to AD conversion. Furthermore, elevated body fluid cytokine levels may correlate with an increased risk of conversion from MCI to AD. Yet, research results are conflicting. To overcome interindividual variances and to obtain a more definite description of cytokine regulation and function in neurodegeneration, a high degree of methodical standardization and patients collective characterization, together with longitudinal sampling over years is essential. The online version of this article (doi:10.1007/s12035-014-8657-1) contains supplementary material, which is available to authorized users.
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DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM
影响因子：
2.4
作者：
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通讯作者：
Humpel, C
DOI：
10.3988/jcn.2008.4.2.84
发表时间：
2008-06
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
--
作者：
Choi C;Jeong JH;Jang JS;Choi K;Lee J;Kwon J;Choi KG;Lee JS;Kang SW
通讯作者：
Kang SW
影响因子：
0.8
作者：
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通讯作者：
Kramer JH
影响因子：
3.7
作者：
Bjorkqvist, Maria;Ohlsson, Mattias;Hansson, Oskar
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Hansson, Oskar