Cherenkov imaging for Total Skin Electron Therapy - an evaluation of dose uniformity.

Cherenkov imaging for Total Skin Electron Therapy - an evaluation of dose uniformity.
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用于全皮肤电子治疗的切伦科夫成像 - 剂量均匀性的评估。

DOI:
10.1117/12.2583939
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发表时间:
2021
期刊:
Proceedings of SPIE--the International Society for Optical Engineering
影响因子:
--
通讯作者:
Pogue,BrianW
Pogue,BrianW
中科院分区:
--
文献类型:
--
作者:
Zhu,TimothyC;Ong,Yihong;Sun,Hongjin;Zhong,Weili;Miao,Tianshun;Dimofte,Andreea;Bruza,Petr;Maity,Amit;Plastaras,JohnP;Paydar,Ima;Dong,Lei;Pogue,BrianW

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全皮肤电子疗法(TSET)利用高能电子治疗整个身体表面的癌症。另外不可见的辐射束可以经由从高能电子束与组织之间的相互作用发射的光学切伦科夫光子来观察。切伦科夫发射可用于使用时间选通增强相机系统实时评估患者表面上的剂量均匀性。在TSET期间,通过体内探测器(IVD)以及闪烁器监测每例患者。对在各种条件下(全身和半身)接受TSET的患者进行成像和分析。一种将切伦科夫强度转换为表面剂量的严格方法,作为校正因子的乘积,包括相机晕影校正因子、入射辐射校正因子和组织光学特性校正因子。通过检查患者相对于脐点(处方点)的各种位置,如头顶、胸部、会阴、胫骨和足部,进行了全面的研究。
Total Skin Electron Therapy (TSET) utilizes high-energy electrons to treat cancers on the entire body surface. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interaction between the high-energy electron beam and tissue. Cherenkov emission can be used to evaluate the dose uniformity on the surface of the patient in real-time using a time-gated intensified camera system. Each patient was monitored during TSET by in-vivo detectors (IVD) as well as Scintillators. Patients undergoing TSET in various conditions (whole body and half body) were imaged and analyzed. A rigorous methodology for converting Cherenkov intensity to surface dose as products of correction factors, including camera vignette correction factor, incident radiation correction factor, and tissue optical properties correction factor. A comprehensive study has been carried out by inspecting various positions on the patients such as vertex, chest, perineum, shins, and foot relative to the umbilicus point (the prescription point).
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