Cortical and Subcortical Circuits for Cross-Modal Plasticity Induced by Loss of Vision.
Cortical and Subcortical Circuits for Cross-Modal Plasticity Induced by Loss of Vision.
复制标题
视觉丧失引起的跨模态可塑性的皮层和皮层下回路。
DOI：
10.3389/fncir.2021.665009
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发表时间：
2021
影响因子：
3.5
通讯作者：
Lee HK
中科院分区：
文献类型：
--
作者：
Ewall G;Parkins S;Lin A;Jaoui Y;Lee HK
皮层区域通过皮层和皮层下通路高度互连，初级感觉皮层并不与这种总体结构隔离。在初级感觉皮层区域，这些预先存在的功能连接可以为感觉处理提供上下文信息，并且可以在感觉模式丢失时调节适应。广义上的跨模态可塑性是指大脑中广泛的可塑性，以响应失去感觉模态，并且主要涉及两个不同的变化：跨模态招募和补偿可塑性。前者涉及招募被剥夺的感觉区域，其中包括被剥夺的初级感觉皮层，以处理剩余的感觉。补偿可塑性是指剩余感觉区域（包括幸存的初级感觉皮层）的可塑性，以增强其自身感觉输入的处理。在这里，我们将总结涉及跨模式招募和代偿可塑性的潜在细胞可塑性机制，并回顾初级感觉皮层的皮层和皮层下回路，这些回路可以在视力丧失时介导跨模式可塑性。
Cortical areas are highly interconnected both via cortical and subcortical pathways, and primary sensory cortices are not isolated from this general structure. In primary sensory cortical areas, these pre-existing functional connections serve to provide contextual information for sensory processing and can mediate adaptation when a sensory modality is lost. Cross-modal plasticity in broad terms refers to widespread plasticity across the brain in response to losing a sensory modality, and largely involves two distinct changes: cross-modal recruitment and compensatory plasticity. The former involves recruitment of the deprived sensory area, which includes the deprived primary sensory cortex, for processing the remaining senses. Compensatory plasticity refers to plasticity in the remaining sensory areas, including the spared primary sensory cortices, to enhance the processing of its own sensory inputs. Here, we will summarize potential cellular plasticity mechanisms involved in cross-modal recruitment and compensatory plasticity, and review cortical and subcortical circuits to the primary sensory cortices which can mediate cross-modal plasticity upon loss of vision.
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影响因子：
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