Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats.
Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats.
复制标题
大鼠内侧缰核慢性注入甲氨基甲胺对尼古丁自身给药的影响。
DOI：
10.1016/j.bbr.2021.113574
复制
发表时间：
2022-01-07
影响因子：
2.7
通讯作者：
Rose JE
中科院分区：
文献类型：
--
作者：
Levin ED;Wells C;Slade S;Johnson J;Petro A;Rezvani AH;Rose JE
缰带是一种上皮结构，从端脑到脑干的下行连接通过缰带连接，使缰带处于一个关键位置，对从脑干到端脑的上行投射提供反馈控制。内侧束有高浓度的烟碱受体。我们评估了内侧habenular尼古丁受体在雌性年轻成年Sprague-Dawley大鼠尼古丁自我给药（SA）中的作用。将双侧慢性输注套管置入内侧缰核。每根套管连接慢速渗透微型泵，长期输注甲胺（100 μg/侧/天）或载药，连续四周。在甲胺输注前两周对大鼠进行尼古丁SA检测。然后，他们有一个星期的强制禁欲，在此期间他们无法获得尼古丁SA。最后，他们恢复了一周的尼古丁SA。预处理基线尼古丁SA较低和较高的动物对甲胺的影响有显著差异。基线尼古丁SA水平较低的大鼠表现出几乎显著的甲胺胺诱导的SA减少，而基线SA水平较高的大鼠表现出显著的甲胺胺诱导的尼古丁SA增加。本研究确定内侧habenular尼古丁受体在尼古丁强化中起重要作用。基线水平的表现对于尼古丁强化的habenular机制的参与有着至关重要的影响，尼古丁激活对于维持尼古丁自我给药对于基线水平较低的人来说是重要的，而对于基线水平较高的人来说则相反。
The habenula is an epithalamic structure through which descending connections go from the telencephalon to the brainstem, putting it in a key location to provide feedback control over the ascending projections from the brainstem to the telencephalon. The medial habenula has a high concentration of nicotinic receptors. We assessed the role of medial habenular nicotinic receptors for nicotine self-administration (SA) in female young adult Sprague-Dawley rats. The rats had bilateral chronic infusion cannulae placed into the medial habenula nucleus. Each cannula was connected to a slow delivery osmotic minipump to chronically infuse mecamylamine (100 μg/side/day) or vehicle for four consecutive weeks. The rats were tested for nicotine SA for the first two weeks of mecamylamine infusion. Then, they had one week of enforced abstinence, during which they had no access to the nicotine SA. Finally, they had one week of resumed nicotine SA access. There was a significantly differential mecamylamine effects in animals with lower and higher pretreatment baseline nicotine SA. Rats with lower baseline nicotine SA levels showed a nearly significant mecamylamine-induced reduction in SA while those with higher baseline levels of SA showed a significant mecamylamine-induced increase in nicotine SA. This study determined that medial habenular nicotinic receptors are important for nicotine reinforcement. Baseline level of performance makes a crucial difference for the involvement of habenular mechanisms in nicotine reinforcement with nicotinic activation being important for maintaining nicotine self-administration for those with lower levels of baseline self-administration and the opposite effect with subjects with higher levels of baseline self-administration.
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影响因子：
4.7
作者：
McLaughlin I;Dani JA;De Biasi M
通讯作者：
De Biasi M
影响因子：
5.6
作者：
Ellison, G
通讯作者：
Ellison, G
影响因子：
2.9
作者：
Carlson, J;Noguchi, K;Ellison, G
通讯作者：
Ellison, G
影响因子：
4.7
作者：
Quick, MW;Ceballos, RM;Lester, RAJ
通讯作者：
Lester, RAJ
介导α3Beta4烟碱拮抗剂的脑区域18-MC对甲基苯丙胺和蔗糖自我给药的影响。
影响因子：
5
作者：
Glick SD;Sell EM;Maisonneuve IM
通讯作者：
Maisonneuve IM