Relationships between skin temperature and temporal summation of heat and cold pain.
Relationships between skin temperature and temporal summation of heat and cold pain.
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皮肤温度与冷热疼痛时间总和之间的关系。
DOI：
10.1152/jn.01066.2002
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Shen,Chiayi
中科院分区：
文献类型：
--
作者：
Mauderli,AndreP;VierckJr,CharlesJ;Cannon,RichardL;Rodrigues,Anthony;Shen,Chiayi
重复刺激时热痛的时间总和依赖于中枢N-甲基-D-天冬氨酸(NMDA)受体机制的C伤害性感受器激活。适度的时间总和是由连续的三角形刺激坡道产生的，它控制着热脉冲之间的皮肤温度，但不会引起明显的第一次和第二次痛感。第二次疼痛的戏剧性总和是通过皮肤与预热热模式的反复接触而产生的，但两次击打之间的皮肤温度不受此过程的控制。因此，在一系列重复的皮肤接触中，皮肤温度记录和热痛的心理物理分级之间的关系被评估。体表和皮下皮肤温度记录显示，在2到8 S的刺激间隔内，热刺激对热刺激具有有效的热调节补偿作用。热痛的时间总和受到刺激间间隔的强烈影响，不能用两次刺激之间皮肤温度的小幅上升或整个刺激系列的热储存来解释。利用重复的短暂接触预冷的热模式来评估是否发生暂时的冷痛总和，如果是，是否受皮肤温度的影响。体表和皮下皮肤温度记录显示，重复的冷刺激对体温调节补偿迟缓。与热刺激相反，在S 3~8岁的ISIS中，冷刺激之间的皮肤温度始终没有恢复。从心理生理上讲，重复的冷刺激产生一种疼痛的感觉，并逐渐发展并辐射到刺激部位之外。疼痛的程度与皮肤温度有很好的相关性，因此似乎主要是由周围因素确定的。
Temporal summation of heat pain during repetitive stimulation is dependent on C nociceptor activation of centralN-methyl-d-aspartate (NMDA) receptor mechanisms. Moderate temporal summation is produced by sequential triangular ramps of stimulation that control skin temperature between heat pulses but do not elicit distinct first and second pain sensations. Dramatic summation of second pain is produced by repeated contact of the skin with a preheated thermode, but skin temperature between taps is not controlled by this procedure. Therefore relationships between recordings of skin temperature and psychophysical ratings of heat pain were evaluated during series of repeated skin contacts. Surface and subcutaneous recordings of skin temperatures revealed efficient thermoregulatory compensation for heat stimulation at interstimulus intervals (ISIs) ranging from 2 to 8 s. Temporal summation of heat pain was strongly influenced by the ISIs and cannot be explained by small increases in skin temperature between taps or by heat storage throughout a stimulus series. Repetitive brief contact with a precooled thermode was utilized to evaluate whether temporal summation of cold pain occurs, and if so, whether it is influenced by skin temperature. Surface and subcutaneous recordings of skin temperature revealed a sluggish thermoregulatory compensation for repetitive cold stimulation. In contrast to heat stimulation, skin temperature did not recover between cold stimuli throughout ISIs of 3–8 s. Psychophysically, repetitive cold stimulation produced an aching pain sensation that progressed gradually and radiated beyond the site of stimulation. The magnitude of aching pain was well related to skin temperature and thus appeared to be established primarily by peripheral factors.
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