Dietary Patterns and Hepatocellular Carcinoma Risk among US Adults.
Dietary Patterns and Hepatocellular Carcinoma Risk among US Adults.
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DOI：
10.3390/nu13062011
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发表时间：
2021-06-11
期刊：
影响因子：
5.9
通讯作者：
Hassan MM
中科院分区：
文献类型：
--
作者：
Moussa I;Day RS;Li R;Du XL;Kaseb AO;Jalal PK;Daniel-MacDougall C;Hatia RI;Abdelhakeem A;Rashid A;Chun YS;Li D;Hassan MM
本研究的目的是在一项以医院为基础的病例对照研究中评估美国成年人饮食模式与肝细胞癌（HCC）风险之间的关系。我们分析了2001年至2018年期间在德克萨斯大学MD安德森癌症中心招募的641例病例和1002例对照组的数据。病例为病理或影像学证实为HCC新诊断的患者；对照组为非胃肠道、肺癌、肝癌或头颈癌患者的无癌配偶。病例和对照组按年龄和性别进行频率匹配。通过主成分分析确定饮食模式。比值比（ORs）和相应的置信区间（CIs）通过调整主要HCC危险因素（包括乙型肝炎病毒和丙型肝炎病毒感染）的无条件逻辑回归计算。以蔬菜为基础的饮食模式与HCC风险呈负相关（最高与最低比值：OR 0.66, 95% CI 0.46-0.94）。西方饮食模式与HCC风险直接相关（最高与最低比值：OR 1.79, 95% CI 1.19-2.69）。这些发现强调了饮食摄入在HCC预防和临床管理中的潜在作用。
The objective of this study was to assess the association between dietary patterns and risk of hepatocellular carcinoma (HCC) among US adults in a hospital-based case-control study. We analyzed data from 641 cases and 1002 controls recruited at The University of Texas MD Anderson Cancer Center during 2001–2018. Cases were patients with a pathologically or radiologically confirmed new diagnosis of HCC; controls were cancer-free spouses of patients with cancers other than gastrointestinal, lung, liver, or head and neck cancer. Cases and controls were frequency-matched by age and sex. Dietary patterns were identified by principal component analysis. Odds ratios (ORs) and corresponding confidence intervals (CIs) were computed using unconditional logistic regression with adjustment for major HCC risk factors, including hepatitis B virus and hepatitis C virus infection. A vegetable-based dietary pattern was inversely associated with HCC risk (highest compared with lowest tertile: OR 0.66, 95% CI 0.46–0.94). A Western diet pattern was directly associated with HCC risk (highest compared with lowest tertile: OR 1.79, 95% CI 1.19–2.69). These findings emphasize the potential role of dietary intake in HCC prevention and clinical management.
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影响因子：
5.5
作者：
SPITZ, MR;FUEGER, JJ;NEWELL, GR
通讯作者：
NEWELL, GR
影响因子：
29.4
作者：
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通讯作者：
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影响因子：
13.5
作者：
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通讯作者：
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作者：
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影响因子：
45.3
作者：
Altekruse, Sean F.;McGlynn, Katherine A.;Reichman, Marsha E.
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