Epidemiology of hepatocellular carcinoma in the United States: where are we? Where do we go?
Epidemiology of hepatocellular carcinoma in the United States: where are we? Where do we go?
复制标题
美国肝细胞癌的流行病学：我们在哪里？我们去哪里？
DOI：
10.1002/hep.27222
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发表时间：
2014-11
期刊：
影响因子：
13.5
通讯作者：
Kanwal, Fasiha
中科院分区：
文献类型：
--
作者：
El-Serag, Hashem B.;Kanwal, Fasiha
自20世纪80年代初以来，肝细胞癌（HCC）在美国的发病率几乎增加了两倍，在那里它是癌症相关死亡中增长最快的原因。1根据基于人群的监测流行病学和最终结果登记数据，2010年肝脏和肝内管癌的总体年龄调整发生率高达8 / 10万潜在人群（图1），其中至少6 / 10万与HCC相关。男性的患病风险大约是女性的三倍。亚洲男性（即中国人、韩国人、菲律宾人和日本人）的年龄调整发病率最高。然而，增幅最大的是西班牙裔，其次是黑人和非西班牙裔白人，而增幅最低的是亚洲人。与亚洲人/太平洋岛民相比，据报道，在美国出生的西班牙裔美国人的HCC发病率高于在外国出生的西班牙裔美国人。2在1900年至1993年出生的每个连续出生队列中，HCC发病率都在增加（图2）。此外，HCC患者的年龄分布也向低龄化转移，其中45-60岁人群的比例增长最大（图2）。HCC的发病率和死亡率呈从南到北的梯度；南部各州，包括德克萨斯州、路易斯安那州和密西西比州，是全国HCC发病率最高的州（图3）。在一项研究中，德克萨斯拉丁裔，特别是南德克萨斯拉丁裔的年龄调整后HCC发病率最高（高达10.6 / 10万）。4
The incidence of hepatocellular carcinoma (HCC) has almost tripled since the early 1980s in the United States, where it is the fastest rising cause of cancerrelated deaths. 1 According to population-based Surveillance Epidemiology and End Results registry data, the overall HCC age-adjusted incidence rates for liver and intrahepatic ducts cancer is as high as 8 per 100,000 underlying population in 2010 (Fig. 1) of which at least 6 per 100,000 are related to HCC. Men are at approximately three times higher risk than women. Asian men (ie, Chinese, Korean, Filipino, and Japanese) have the highest age-adjusted incidence rates. However, the largest proportional increases have occurred among Hispanics followed by blacks and non-Hispanic whites, whereas the lowest proportional increases have occurred among Asians. In contrast to Asians/Pacific Islanders, HCC incidence rates are reported to be higher among Hispanics born in the United States than among foreign-born Hispanics. 2 HCC incidence rates have increased in each successive birth cohort born between 1900 and 19593 (Fig. 2). In addition, the age distribution of HCC patients has shifted to younger ages, with the greatest proportional increases among individuals 45-60 years old (Fig. 2). There is a south to north gradient in the incidence and mortality of HCC; southern states, including Texas, Louisiana, and Mississippi, have some of the highest HCC incidence rates in the nation (Fig. 3). In one study, Texas Latinos and, especially, South Texas Latinos had the highest age-adjusted HCC incidence rates (as high as 10.6 per 100,000). 4
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