Lung perfusion measured using magnetic resonance imaging: New tools for physiological insights into the pulmonary circulation.
Lung perfusion measured using magnetic resonance imaging: New tools for physiological insights into the pulmonary circulation.
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DOI：
10.1002/jmri.22378
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发表时间：
2010-12
影响因子：
4.4
通讯作者：
Prisk, G. Kim
中科院分区：
文献类型：
--
作者：
Hopkins, Susan R.;Prisk, G. Kim
因为肺接收整个心输出量，所以不需要复杂的成像技术来测量器官的总灌注量。然而，多年来，研究肺功能一直要求生理学家将肺视为单一实体：在成像方面，将其视为单一体素。由于成像，特别是功能成像，允许获取对研究肺功能重要的空间信息，这些技术提供了相当大的前景，并引起了肺生理学家的极大兴趣。特别是，尽管肺部存在低质子密度和短T2*的挑战，但非对比MRI技术测量肺血流灌注具有几个优点，包括高可靠性和能够在多种生理条件下重复测量。本文主要介绍一种特殊的动脉自旋标记(ASL)技术--ASL-FIRER(利用额外的射频脉冲进行血流敏感的反转恢复)在回答健康和疾病中与肺功能相关的生理学问题方面的应用。还讨论了相关的区域质子密度测量以校正基于重力的肺变形(“Slinky”效应(Slinky是PaufSlinky公司的注册商标))以及与绝对量化相关的问题。
Since the lung receives the entire cardiac output, sophisticated imaging techniques are not required in order to measure total organ perfusion. However, for many years studying lung function has required physiologists to consider the lung as a single entity: in imaging terms as a single voxel. Since imaging, and in particular functional imaging, allows the acquisition of spatial information important for studying lung function, these techniques provide considerable promise and are of great interest for pulmonary physiologists. In particular, despite the challenges of low proton density and short T2* in the lung, noncontrast MRI techniques to measure pulmonary perfusion have several advantages including high reliability and the ability to make repeated measurements under a number of physiologic conditions. This brief review focuses on the application of a particular arterial spin labeling (ASL) technique, ASL-FAIRER (flow sensitive inversion recovery with an extra radiofrequency pulse), to answer physiologic questions related to pulmonary function in health and disease. The associated measurement of regional proton density to correct for gravitational-based lung deformation (the “Slinky” effect (Slinky is a registered trademark of PaufSlinky incorporated)) and issues related to absolute quantification are also discussed.
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