RNA Motifs and Modification Involve in RNA Long-Distance Transport in Plants.
RNA Motifs and Modification Involve in RNA Long-Distance Transport in Plants.
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RNA基序和修饰参与植物中RNA的长距离运输
DOI：
10.3389/fcell.2021.651278
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发表时间：
2021
影响因子：
5.5
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Wang T;Li X;Zhang X;Wang Q;Liu W;Lu X;Gao S;Liu Z;Liu M;Gao L;Zhang W
在高等植物的韧皮部中发现了大量的RNA分子，它们可以通过韧皮部运输到远处的细胞器中。RNA信号是在遭受各种生理挑战时通过长距离运输进行强化策略进化的重要线索。到目前为止，RNA通过韧皮部细胞选择性运输的机制仍在研究中。到目前为止，已有证据表明，多聚嘧啶（poly-CU）序列、转运RNA（tRNA）相关序列、单核苷酸突变（SingleNucleotideMutation）等RNA基序与特异性RNA结合蛋白结合形成核糖核苷酸蛋白（RibonucleotideProtein，RNP）复合物，可以促进RNA在植物体内的移动。此外，RNA的二级结构如tRNA样结构（TLS）、mRNA的非翻译区（UTR）、pre-miRNA的茎环结构等也对RNA的迁移性有一定的影响。最新研究发现，RNA甲基化如甲基化5′胞嘧啶（methylated 5′ cytosine，m5 C）在RNA的转运和功能中起着重要作用。这些研究为揭示RNA的转运机制奠定了理论基础。本文旨在为进一步研究RNA模体在RNA长距离运输中的作用提供思路和线索，进而探索RNA系统信号转导的内在机制。
A large number of RNA molecules have been found in the phloem of higher plants, and they can be transported to distant organelles through the phloem. RNA signals are important cues to be evolving in fortification strategies by long-distance transportation when suffering from various physiological challenges. So far, the mechanism of RNA selectively transportation through phloem cells is still in progress. Up to now, evidence have shown that several RNA motifs including Polypyrimidine (poly-CU) sequence, transfer RNA (tRNA)-related sequence, Single Nucleotide Mutation bound with specific RNA binding proteins to form Ribonucleotide protein (RNP) complexes could facilitate RNA mobility in plants. Furthermore, some RNA secondary structure such as tRNA-like structure (TLS), untranslation region (UTR) of mRNA, stem-loop structure of pre-miRNA also contributed to the mobility of RNAs. Latest researchs found that RNA methylation such as methylated 5′ cytosine (m5C) played an important role in RNA transport and function. These studies lay a theoretical foundation to uncover the mechanism of RNA transport. We aim to provide ideas and clues to inspire future research on the function of RNA motifs in RNA long-distance transport, furthermore to explore the underlying mechanism of RNA systematic signaling.
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