Association of serum cholesterol with Parkinson's disease in a cohort of statin-free individuals.
Association of serum cholesterol with Parkinson's disease in a cohort of statin-free individuals.
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DOI：
10.1002/brb3.2454
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发表时间：
2022-01
影响因子：
3.1
通讯作者：
Li N
中科院分区：
文献类型：
--
作者：
Lv Y;Xu B;Zhang X;Chen C;Gao Y;Li N
血清胆固醇在帕金森病（PD）发病机制中的作用仍不清楚。本研究的目的是评估一组新诊断的未使用他汀类药物的帕金森病患者血清胆固醇与帕金森病之间的关联。这项回顾性研究使用了从 672 名连续未使用他汀类药物的新诊断 PD 个体和 540 名对照者获得的空腹血脂谱。这些PD个体是在2017-2021年期间从三个医疗机构中识别出来的，而对照是在同一时期从三个体检中心中识别出来的。使用逻辑回归来估计比值比 (OR) 和 95% 置信区间 (CI)，并调整年龄、性别和烟草使用史。在 672 名 PD 个体中，根据现行标准排除了 112 名 PD 患者，剩下 560 名 PD 患者。多变量二元 Logistic 回归分析显示，在调整年龄、性别和吸烟史后，LDL-C 是导致 PD 发生的唯一变量（OR 1.39，95% CI：1.07-2.31，p < .001）；在进一步调整 TC 和 HDL-C 后，这种关联仍然存在。在校正 TC 和 HDL-C 后 LDL-C 调整结果的亚组分析中，较低的 LDL-C 与较高的 PD 风险相关。在选定的未使用他汀类药物的新诊断 PD 个体人群中，低 LDL-C 可能与 PD 的发生有关。 PD 与血清胆固醇相关的流行病学证据尚未得到很好的描述。在选定的未使用他汀类药物的新诊断 PD 个体中，低 LDL-C 可能与 PD 的发生有关。
The role of serum cholesterol in the pathogenesis of Parkinson's disease (PD) remains unclear. The objective of this study was to assess the association between serum cholesterol and PD in a cohort of statin‐free newly diagnosed PD patients. This retrospective study used fasting lipid profiles obtained from 672 consecutive statin‐free newly diagnosed PD individuals and 540 controls. These PD individuals were identified from three medical institutions during 2017–2021, and the controls were identified from three physical examination centers during the same time period. Logistic regressions were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), with adjustment of age, sex, and tobacco use history. Among 672 PD individuals, 112 were excluded in accordance with the current criteria, leaving 560 PD patients. The multivariate binary logistic regression analysis showed that LDL‐C was the only variable contributing to the occurrence of PD (OR 1.39, 95% CI: 1.07‐2.31, p < .001) after adjusting for age, sex, and tobacco use history; this association persisted following further adjustment for TC and HDL‐C. In the subgroup analysis of the adjusted results of LDL‐C after correcting for TC and HDL‐C, lower LDL‐C was associated with a higher risk of PD. Among selected populations of statin‐free newly diagnosed PD individuals, low LDL‐C might be associated with the occurrence of PD. Epidemiological evidence on PD with respect to serum cholesterol has not been well delineated. Among selected populations of statin‐free, newly diagnosed PD individuals, low LDL‐C might be associated with the occurrence of PD.
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影响因子：
3.7
作者：
Huang X;Auinger P;Eberly S;Oakes D;Schwarzschild M;Ascherio A;Mailman R;Chen H;Parkinson Study Group DATATOP Investigators
通讯作者：
Parkinson Study Group DATATOP Investigators
帕金森氏病患者的血清脂质谱：伊朗西北部的一项研究。
影响因子：
1.4
作者：
Saedi S;Hemmati-Dinarvand M;Barmaki H;Mokhtari Z;Musavi H;Valilo M;Mota A;Mahjoub S
通讯作者：
Mahjoub S
影响因子：
7.4
作者：
Sterling NW;Lichtenstein M;Lee EY;Lewis MM;Evans A;Eslinger PJ;Du G;Gao X;Chen H;Kong L;Huang X
通讯作者：
Huang X
影响因子：
0.7
作者：
Bao, Minqiang;Hu, Renping;Xue, Qun
通讯作者：
Xue, Qun
影响因子：
5.2
作者：
Trupp, Miles;Jonsson, Par;Forsgren, Lars
通讯作者：
Forsgren, Lars