Neurotensin, a Novel Messenger to Cross-Link Inflammation and Tumor Invasion via Epithelial-Mesenchymal Transition Pathway
Neurotensin, a Novel Messenger to Cross-Link Inflammation and Tumor Invasion via Epithelial-Mesenchymal Transition Pathway
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神经降压素，一种通过上皮-间质转化途径交联炎症和肿瘤侵袭的新型信使
DOI：
10.3109/08830185.2014.952412
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发表时间：
2014-09
影响因子：
5
通讯作者：
Yu, Jinpu
中科院分区：
文献类型：
--
作者：
Wei, Feng;Cheng, Yanan;Han, Lei;Yu, Jinpu
多种细胞因子和生长因子对于癌症的预后至关重要，癌症已被视为全球健康问题。最近，调节中枢神经系统一系列功能的可溶性因子神经肽也被证明可以刺激肿瘤细胞的增殖和迁移。在这些信号肽中，神经降压素（NTS）在恶性肿瘤进展中的作用已成为热门话题。 NTS 对肿瘤生长的影响及其抗细胞凋亡作用已被确定。随后，研究证实了NTS对迁移和侵袭的影响，但目前所涉及的分子机制仍不清楚。最近有报道表明NTS可以诱导白细胞介素8（IL-8）的表达和分泌，促进局部炎症反应，可能参与上皮间质转化（EMT）相关的肿瘤迁移。本文重点介绍NTS通过刺激IL-8诱导肿瘤EMT的过程以及NTS/IL-8通路在临床应用前景的意义。
Multiple cytokines and growth factors are critical for the prognosis of cancer which has been regarded as a worldwide health problem. Recently, neuropeptides, soluble factors regulating a series of functions in the central nervous system, have also been demonstrated to stimulate the proliferation and migration of tumor cells. Among these signaling peptides, the role of neurotensin (NTS) on malignancy procession has become a hot topic. The effects of NTS on tumor growth and its antiapoptosis role have already been identified. Subsequently, studies demonstrated the impact of NTS on the migration and invasion, but the molecular mechanisms involved are still unclear at present. Recently, some reports indicated that NTS could induce expression and secretion of interleukin-8 (IL-8) to promote local imflammatory response which might participate in epithelial-mesenchymal transition (EMT)-related tumor migration. In present review, we highlight the process of tumor EMT induced by NTS through stimulating IL-8 and the significance of NTS/IL-8 pathway in clinical application prospect.
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影响因子：
4.8
作者：
Knall, C;Young, S;Johnson, GL
通讯作者：
Johnson, GL
影响因子：
11.2
作者：
Sylvia Grille;A. Bellacosa;J. Upson;Andres J Klein-Szanto;F. van Roy;W. Lee‐Kwon;M. Donowitz;P. T
通讯作者：
Sylvia Grille;A. Bellacosa;J. Upson;Andres J Klein-Szanto;F. van Roy;W. Lee‐Kwon;M. Donowitz;P. T
影响因子：
--
作者：
Grosse-Steffen T;Giese T;Giese N;Longerich T;Schirmacher P;Hänsch GM;Gaida MM
通讯作者：
Gaida MM
影响因子：
6.1
作者：
R. Robbins;K. J. Nelson;G. Gossman;I. Rubinstein
通讯作者：
R. Robbins;K. J. Nelson;G. Gossman;I. Rubinstein
影响因子：
6.4
作者：
Dal Farra, C;Sarret, P;Vincent, JP
通讯作者：
Vincent, JP