Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders.
Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders.
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DOI：
10.1007/s11920-017-0772-z
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发表时间：
2017-04
影响因子：
6.7
通讯作者：
Boland EM
中科院分区：
文献类型：
--
作者：
Alloy LB;Ng TH;Titone MK;Boland EM
我们回顾了双相谱系障碍（BSD）昼夜节律失调的最新证据。我们研究的证据内源性异常的生物钟和中断的外部夹带的昼夜节律在BSD。我们还讨论了昼夜节律失调是否提供了脆弱性的BSD和证据的一个新的整合奖励和昼夜节律失调的BSD发作。相对昼夜节律相位延迟（例如，较晚的褪黑激素峰值，晚上的生理时钟型）与BSD相关，特别是在抑郁阶段。更一致的证据支持社会节奏，睡眠/觉醒和活动模式的不规则性，以及生活事件对社会节奏的破坏，作为BSD的稳定特征标记和BSD发作的潜在脆弱性。越来越多的研究支持一个综合的奖励/昼夜节律模型。生物钟起搏功能的内源性异常和生理和社会线索对昼夜节律的外部诱导的破坏都参与了BSD。昼夜节律失调可能会导致BSD发作。
We review recent evidence for circadian rhythm dysregulation in bipolar spectrum disorders (BSDs). We examine evidence for endogenous abnormalities in the biological clock and disruptions in the external entrainment of circadian rhythms in BSDs. We also address whether circadian dysregulation provides vulnerability to onset of BSD and evidence for a new integration of reward and circadian dysregulation in BSD. Relative circadian phase delay (e.g., later melatonin peak, evening chronotype) is associated with BSD, particularly in the depressive phase. More consistent evidence supports irregularity of social rhythms, sleep/wake and activity patterns, and disruptions of social rhythms by life events, as stable trait markers of BSD and potential vulnerabilities for BSD onset. Growing research supports an integrative reward/circadian model. Both endogenous abnormalities in the biological clock pacemaking function and disruptions in the external entrainment of circadian rhythms by physical and social cues are involved in BSDs. Circadian dysregulation may provide vulnerability to BSD onset.
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影响因子：
4.8
作者：
Albrecht U
通讯作者：
Albrecht U
影响因子：
4.6
作者：
Alloy LB;Boland EM;Ng TH;Whitehouse WG;Abramson LY
通讯作者：
Abramson LY
沿双极光谱的进展：从双极光谱条件转换为双极I和II疾病的纵向研究。
影响因子：
4.6
作者：
Alloy LB;Urošević S;Abramson LY;Jager-Hyman S;Nusslock R;Whitehouse WG;Hogan M
通讯作者：
Hogan M
影响因子：
2.8
作者：
Boudebesse, C.;Lajnef, M.;Etain, B.
通讯作者：
Etain, B.
影响因子：
3.1
作者：
Baek, Ji Hyun;Kim, Ji Sun;Hong, Kyung Sue
通讯作者：
Hong, Kyung Sue