A Systematic Review of the Self-Medication Hypothesis in the Context of Posttraumatic Stress Disorder and Comorbid Problematic Alcohol Use.
A Systematic Review of the Self-Medication Hypothesis in the Context of Posttraumatic Stress Disorder and Comorbid Problematic Alcohol Use.
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DOI：
10.1002/jts.22521
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发表时间：
2020-10
影响因子：
3.3
通讯作者：
Amstadter AB
中科院分区：
文献类型：
--
作者：
Hawn SE;Cusack SE;Amstadter AB
创伤后应激障碍（PTSD）和酒精使用障碍（AUD）通常同时发生，并与许多负面的公共卫生结果有关。有几种病因学模型可以解释PTSD和AUD之间的重叠，包括共享遗传风险和表型因果关系，但病因学关联的主要模型是饮酒科普自我药物模型。虽然自我药疗模型在概念上很吸引人，并且在研究酒精使用和焦虑的文献中被广泛接受（例如，PTSD）表型，研究结果是不一致的，缺乏严格的经验证据支持这一模型。这篇综述，据我们所知，是第一个系统性回顾自我药疗模式与PTSD的日期，旨在综合目前的文献中的自我药疗模式的背景下，PTSD和有问题的酒精使用之间的关联。共有24项研究符合纳入标准，并使用各种测量工具和数据分析方法（如中介，适度和回归）评估了自我药疗假设。总体而言，纳入的研究为自我药疗假设提供了证据，但由于方法学的局限性，其严谨性有限。这些限制，其中包括与创伤相关的饮酒，以应付操作化（或缺乏）的问题，进行了讨论，并提出了未来的研究方向。
Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) commonly co-occur and are associated with many negative public health outcomes. There are several etiological models that explain the overlap between PTSD and AUD, including shared genetic risk and phenotypic causality, but the predominant model of etiologic association is the drinking-to-cope self-medication model. Although the self-medication model is conceptually appealing and has been widely accepted within the literature examining alcohol use and anxiety (e.g., PTSD) phenotypes, the findings are inconsistent and there is a lack of rigorous empirical evidence in support of this model. This review, which was, to our knowledge, the first systematic review of the self-medication model in relation to PTSD to date, aimed to synthesize the current literature on the association between PTSD and problematic alcohol use within the context of the self-medication model. In total, 24 studies met the inclusion criteria for the review and assessed the self-medication hypothesis using a variety of measurement instruments and data analytic approaches, such as mediation, moderation, and regression. Overall, the included studies provide evidence for the self-medication hypothesis but are limited in rigor due to methodological limitations. These limitations, which include issues with the operationalization (or lack thereof) of trauma-related drinking to cope, are discussed, and directions for future research are presented.
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影响因子：
4.4
作者：
Kaysen, Debra;Dillworth, Tiara M.;Resick, Patricia A.
通讯作者：
Resick, Patricia A.
DOI：
10.1080/1067828x.2013.839407
发表时间：
2015-11-02
影响因子：
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Amstadter, Ananda B.
影响因子：
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作者：
Grant BF;Goldstein RB;Saha TD;Chou SP;Jung J;Zhang H;Pickering RP;Ruan WJ;Smith SM;Huang B;Hasin DS
通讯作者：
Hasin DS
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DOI：
10.15288/jsa.1999.60.694
发表时间：
1999-09-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Carpenter, KM;Hasin, DS
通讯作者：
Hasin, DS