An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide.
An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide.
复制标题
人类主要组织相容性复合体调节区的一种古老平衡多态性在中国少数民族中保留，但在世界范围内丢失。
DOI：
10.1086/500593
复制
发表时间：
2006
影响因子：
9.8
通讯作者：
Xu,Anlong
中科院分区：
文献类型：
--
作者：
Liu,Xiaoyi;Fu,Yonggui;Liu,Zehuan;Lin,Bin;Xie,Yi;Liu,Yin;Xu,Yunpin;Lin,Jianghai;Fan,Xinlan;Dong,Meiling;Zeng,Kai;Wu,Chung-I;Xu,Anlong
The coding regions of many of the major histocompatibility complex (MHC) (human leukocyte antigen [HLA] in humans) molecules are believed to be subject to balancing selection. But it is less certain whether the regulatory regions of such coding sequences are also subject to the same type of selection. Here, we studied the polymorphism of the regulatory regions of theHLA-DPA1andHLA-DPB1genes among ethnic minorities in southwestern China. Phylogenetic analysis revealed two deep clades >10 million years old. There is almost complete linkage disequilibrium between the regulatory and coding regions ofHLA-DPA1,which hints at coadaptive balancing selection on the entire region. Thus, the molecular mechanism of balancing selection in MHC may involve expression modulation in addition to coding-region polymorphisms. Although the frequency of clade II is >30% in some ethnic minorities, it decreases to <5% among southern Han Chinese and vanishes among Europeans. As suspected, some ancient balanced polymorphisms, lost in major populations, still exist in isolated ethnicities. These isolated populations may thus contribute disproportionately to the total diversity of modern humans.
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影响因子：
2.9
作者：
Santos-Garcia MO;Karia CT;Resende RM;Chiari L;Vieira ML;Zucchi MI;Souza AP
通讯作者：
Souza AP
影响因子：
7
作者：
Cowell, LG;Kepler, TB;Mitchison, NA
通讯作者：
Mitchison, NA
影响因子：
9.8
作者：
Chen, FC;Li, WH
通讯作者：
Li, WH
不同单倍型中 HLA-DR 基因的差异转录活性。
影响因子：
4.4
作者：
P. Louis;R. Vincent;P. Cavadore;J. Clot;J. Eliaou
通讯作者：
J. Eliaou
小鼠 MHC 启动子的模式变异
DOI：
10.1073/pnas.152329999
发表时间：
2002
影响因子：
11.1
作者：
N. Mitchison;J. Roes
通讯作者：
J. Roes