Drug resistance phenotypes and genotypes in Mexico in representative gram-negative species: Results from the infivar network.
Drug resistance phenotypes and genotypes in Mexico in representative gram-negative species: Results from the infivar network.
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墨西哥代表性革兰阴性菌的耐药表型和基因型：来自infivar网络的结果。
DOI：
10.1371/journal.pone.0248614
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Camacho-Ortiz A
中科院分区：
文献类型：
--
作者：
Garza-González E;Bocanegra-Ibarias P;Bobadilla-Del-Valle M;Ponce-de-León-Garduño LA;Esteban-Kenel V;Silva-Sánchez J;Garza-Ramos U;Barrios-Camacho H;López-Jácome LE;Colin-Castro CA;Franco-Cendejas R;Flores-Treviño S;Morfín-Otero R;Rojas-Larios F;Mena-Ramírez JP;Fong-Camargo MG;Morales-De-la-Peña CT;García-Mendoza L;Choy-Chang EV;Aviles-Benitez LK;Feliciano-Guzmán JM;López-Gutiérrez E;Gil-Veloz M;Barajas-Magallón JM;Aguirre-Burciaga E;López-Moreno LI;Martínez-Villarreal RT;Canizales-Oviedo JL;Cetina-Umaña CM;Romero-Romero D;Bello-Pazos FD;Barlandas-Rendón NRE;Maldonado-Anicacio JY;Bolado-Martínez E;Galindo-Méndez M;Perez-Vicelis T;Alavez-Ramírez N;Méndez-Sotelo BJ;Cabriales-Zavala JF;Nava-Pacheco YC;Moreno-Méndez MI;García-Romo R;Silva-Gamiño AR;Avalos-Aguilera AM;Santiago-Calderón MA;López-García M;Velázquez-Acosta MDC;Cobos-Canul DI;Vázquez-Larios MDR;Ortiz-Porcayo AE;Guerrero-Núñez AE;Valero-Guzmán J;Rosales-García AA;Ostos-Cantú HL;Camacho-Ortiz A
本报告介绍了墨西哥产超广谱β-内酰胺酶（ESBLs）和代表性产碳青霉烯酶革兰氏阴性菌种的流行率和特征的表型和遗传数据。共有52个中心参与，43个医院实验室和9个外部实验室。使用WHONET 5.6平台分析了2020年1月1日至3月31日期间选定临床标本中大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌复合群、鲍曼不动杆菌复合群和铜绿假单胞菌的耐药性数据分布。从选定标本中回收的临床分离株包括：碳青霉烯类耐药肠杆菌科、ESBL或碳青霉烯类耐药大肠杆菌。coli和K.肺炎克雷伯氏菌、碳青霉烯类耐药A.鲍曼不动杆菌复合体和铜绿假单胞菌。对菌株进行基因分型，以检测ESBL和/或碳青霉烯酶编码基因。血液分离株中，A.鲍曼不动杆菌复合菌对所有抗生素的耐药率均在68%以上，肠杆菌中，E.氯吡格雷复合物对碳青霉烯类抗生素耐药率较高。A.鲍曼不动杆菌复合物对呼吸道标本的耐药率较高，只有阿米卡星的耐药率低于70%。在K. blaTEM、blaSHV和blaCTX的检出率分别为68.79%、72.3%和91.9%。在E.大肠埃希菌、blaTEM、blaSHV和blaCTX的检出率分别为20.8%、4.53%和85.7%。对于这两个物种，最常见的基因型是blaCTX-M-15。在肠杆菌科中，最常见的碳青霉烯酶编码基因是blaNDM-1（81.5%），其次是blaOXA-232（14.8%）和blaoxa-181（7.4%）。鲍曼不动杆菌为blaOXA-24（76%），铜绿假单胞菌为blaIMP（25.3%），其次为blaGES和blaVIM（各13.1%）。我们的研究报告称，NDM-1是墨西哥肠杆菌科中最常见的碳青霉烯酶编码基因，具有苯唑西林酶基因181和232的循环。与拉丁美洲和美国的其他国家相比，科索沃保护团是一个罕见的现象。此外，ESBL blaCTX-M-15在两种E.埃希菌和肺炎。
This report presents phenotypic and genetic data on the prevalence and characteristics of extended-spectrum β-lactamases (ESBLs) and representative carbapenemases-producing Gram-negative species in Mexico. A total of 52 centers participated, 43 hospital-based laboratories and 9 external laboratories. The distribution of antimicrobial resistance data for Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, Acinetobacter baumannii complex, and Pseudomonas aeruginosa in selected clinical specimens from January 1 to March 31, 2020 was analyzed using the WHONET 5.6 platform. The following clinical isolates recovered from selected specimens were included: carbapenem-resistant Enterobacteriaceae, ESBL or carbapenem-resistant E. coli, and K. pneumoniae, carbapenem-resistant A. baumannii complex, and P. aeruginosa. Strains were genotyped to detect ESBL and/or carbapenemase-encoding genes. Among blood isolates, A. baumannii complex showed more than 68% resistance for all antibiotics tested, and among Enterobacteria, E. cloacae complex showed higher resistance to carbapenems. A. baumannii complex showed a higher resistance pattern for respiratory specimens, with only amikacin having a resistance lower than 70%. Among K. pneumoniae isolates, blaTEM, blaSHV, and blaCTX were detected in 68.79%, 72.3%, and 91.9% of isolates, respectively. Among E. coli isolates, blaTEM, blaSHV, and blaCTX were detected in 20.8%, 4.53%, and 85.7% isolates, respectively. For both species, the most frequent genotype was blaCTX-M-15. Among Enterobacteriaceae, the most frequently detected carbapenemase-encoding gene was blaNDM-1 (81.5%), followed by blaOXA-232 (14.8%) and blaoxa-181(7.4%), in A. baumannii was blaOXA-24 (76%) and in P. aeruginosa, was blaIMP (25.3%), followed by blaGES and blaVIM (13.1% each). Our study reports that NDM-1 is the most frequent carbapenemase-encoding gene in Mexico in Enterobacteriaceae with the circulation of the oxacillinase genes 181 and 232. KPC, in contrast to other countries in Latin America and the USA, is a rare occurrence. Additionally, a high circulation of ESBL blaCTX-M-15 exists in both E. coli and K. pneumoniae.
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影响因子：
19
作者：
Albiger, B.;Glasner, C.;Monnet, D. L.
通讯作者：
Monnet, D. L.
影响因子：
4.9
作者：
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11.8
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DOI：
10.1016/j.ijantimicag.2012.08.010
发表时间：
2013-01-01
影响因子：
10.8
作者：
Baroud, M.;Dandache, I.;Matar, G. M.
通讯作者：
Matar, G. M.