Default mode network changes in fibromyalgia patients are largely dependent on current clinical pain.
Default mode network changes in fibromyalgia patients are largely dependent on current clinical pain.
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DOI：
10.1016/j.neuroimage.2020.116877
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发表时间：
2020-08-01
期刊：
影响因子：
5.7
通讯作者：
Catherine Bushnell M
中科院分区：
文献类型：
--
作者：
Čeko M;Frangos E;Gracely J;Richards E;Wang B;Schweinhardt P;Catherine Bushnell M
慢性疼痛患者默认模式网络(DMN)功能磁共振静息状态连通性的差异通常被解释为慢性疼痛条件下的大脑重组。然而，患者在功能磁共振成像时的疼痛可能会影响DMN，因为疼痛与认知刺激一样，涉及注意力机制，而认知参与已知会改变DMN的活动。在这里，我们的目的是将慢性疼痛状态(特征)的影响与当前疼痛体验(状态)对纤维肌痛(FM)患者DMN连接性的影响分开。我们进行了静息状态的fMRI扫描，以测试FM患者和匹配的健康对照组在两个不同的队列中的DMN连接：(1)在扫描过程中没有疼痛的队列(27名FM患者和27名对照组)，(2)在扫描期间有当前临床疼痛的队列(16名FM患者和16名对照组)。在扫描过程中没有疼痛的FM患者中，DMN的连接性与对照组没有显著差异。相比之下，与先前的研究类似，在扫描期间有当前临床疼痛的FM患者显著增加了DMN到双侧前岛(INS)的连接性。回归分析显示DMN-MidINS连通性与当前疼痛呈正相关。因此，我们认为扫描过程中由于当前临床疼痛(当前疼痛状态)导致的短暂DMN中断可能是慢性疼痛患者观察到的DMN连接中断的重要因素。
Differences in fMRI resting-state connectivity of the default mode network (DMN) seen in chronic pain patients are often interpreted as brain reorganization due to the chronic pain condition. Nevertheless, patients’ pain at the time of fMRI might influence the DMN because pain, like cognitive stimuli, engages attentional mechanisms and cognitive engagement is known to alter DMN activity. Here, we aimed to dissociate the influence of chronic pain condition (trait) from the influence of current pain experience (state) on DMN connectivity in patients with fibromyalgia (FM). We performed resting-state fMRI scans to test DMN connectivity in FM patients and matched healthy controls in two separate cohorts: (1) in a cohort not experiencing pain during scanning (27 FM patients and 27 controls), (2) in a cohort with current clinical pain during scanning (16 FM patients and 16 controls). In FM patients without pain during scanning, the connectivity of the DMN did not differ significantly from controls. By contrast, FM patients with current clinical pain during the scan had significantly increased DMN connectivity to bilateral anterior insula (INS) similar to previous studies. Regression analysis showed a positive relationship between DMN-midINS connectivity and current pain. We therefore suggest that transient DMN disruptions due to current clinical pain during scanning (current pain state) may be a substantial contributor to DMN connectivity disruptions observed in chronic pain patients.
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影响因子：
3.7
作者：
Baliki MN;Mansour AR;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
2.9
作者：
Coulombe MA;Lawrence KS;Moulin DE;Morley-Forster P;Shokouhi M;Nielson WR;Davis KD
通讯作者：
Davis KD
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
2.5
作者：
Coghill, RC;Sang, CN;Iadarola, MJ
通讯作者：
Iadarola, MJ
基于ICA的人工制品去除和加速fMRI获取，以改善静止状态网络成像。
影响因子：
5.7
作者：
Griffanti L;Salimi-Khorshidi G;Beckmann CF;Auerbach EJ;Douaud G;Sexton CE;Zsoldos E;Ebmeier KP;Filippini N;Mackay CE;Moeller S;Xu J;Yacoub E;Baselli G;Ugurbil K;Miller KL;Smith SM
通讯作者：
Smith SM