Antibody and B cell responses to SARS-CoV-2 infection and vaccination.
Antibody and B cell responses to SARS-CoV-2 infection and vaccination.
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DOI：
10.1016/j.chom.2021.06.009
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发表时间：
2021-07-14
影响因子：
30.3
通讯作者：
Boyd SD
中科院分区：
文献类型：
--
作者：
Röltgen K;Boyd SD
抗体以及负责产生抗体的B细胞和浆细胞群是人类免疫系统对SARS-CoV-2反应的关键组成部分，SARS-CoV-2导致了2019冠状病毒病（COVID-19）大流行。在这里，我们回顾了针对SARS-CoV-2的抗体反应的性质及其在保护免受感染或调节COVID-19疾病严重程度方面的作用的研究结果。在短短一年多的时间里，人们已经了解到许多关于人类对这种病原体的免疫反应的信息，并在独立研究中进行了复制，这有助于开发有效的疫苗。然而，重要的问题仍然是抗体应答的持续时间和有效性，与疫苗接种相比，来自感染的免疫力之间的差异，血清学结果的细胞基础，以及病毒变异体从当前免疫力中逃逸的程度。Röltgen和Boyd回顾了过去一年的研究，分析了抗体和B细胞对SARS-CoV-2感染和疫苗接种的反应，以及它们预防后续感染的能力。免疫力的持续时间和新的SARS-CoV-2变种的影响是下一阶段大流行的主要问题。
Antibodies, and the B cell and plasma cell populations responsible for their production, are key components of the human immune system’s response to SARS-CoV-2, which has caused the coronavirus disease 2019 (COVID-19) pandemic. Here, we review findings addressing the nature of antibody responses against SARS-CoV-2 and their role in protecting from infection or modulating COVID-19 disease severity. In just over a year, much has been learned, and replicated in independent studies, about human immune responses to this pathogen, contributing to the development of effective vaccines. Nevertheless, important questions remain about the duration and effectiveness of antibody responses, differences between immunity derived from infection compared to vaccination, the cellular basis for serological findings, and the extent to which viral variants will escape from current immunity. Röltgen and Boyd review research in the past year that has analyzed antibody and B cell responses to SARS-CoV-2 infection and vaccination, and their ability to prevent subsequent infection. The duration of immunity and the impact of new SARS-CoV-2 variants are major questions for the pandemic’s next phase.
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影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
64.5
作者：
Dejnirattisai W;Zhou D;Ginn HM;Duyvesteyn HME;Supasa P;Case JB;Zhao Y;Walter TS;Mentzer AJ;Liu C;Wang B;Paesen GC;Slon-Campos J;López-Camacho C;Kafai NM;Bailey AL;Chen RE;Ying B;Thompson C;Bolton J;Fyfe A;Gupta S;Tan TK;Gilbert-Jaramillo J;James W;Knight M;Carroll MW;Skelly D;Dold C;Peng Y;Levin R;Dong T;Pollard AJ;Knight JC;Klenerman P;Temperton N;Hall DR;Williams MA;Paterson NG;Bertram FKR;Siebert CA;Clare DK;Howe A;Radecke J;Song Y;Townsend AR;Huang KA;Fry EE;Mongkolsapaya J;Diamond MS;Ren J;Stuart DI;Screaton GR
通讯作者：
Screaton GR
影响因子：
64.5
作者：
Hoffmann M;Arora P;Groß R;Seidel A;Hörnich BF;Hahn AS;Krüger N;Graichen L;Hofmann-Winkler H;Kempf A;Winkler MS;Schulz S;Jäck HM;Jahrsdörfer B;Schrezenmeier H;Müller M;Kleger A;Münch J;Pöhlmann S
通讯作者：
Pöhlmann S
影响因子：
2.2
作者：
Havenar-Daughton, Colin;Newton, Isabel G.;Crotty, Shane
通讯作者：
Crotty, Shane
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group