The human interleukin-2 receptor: normal and abnormal expression in T cells and in leukemias induced by the human T-lymphotropic retroviruses.
The human interleukin-2 receptor: normal and abnormal expression in T cells and in leukemias induced by the human T-lymphotropic retroviruses.
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人白细胞介素 2 受体：T 细胞和人嗜 T 淋巴细胞逆转录病毒诱导的白血病中的正常和异常表达。
DOI：
10.7326/0003-4819-105-4-560
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发表时间：
1986
影响因子：
39.2
通讯作者：
T. Waldmann
中科院分区：
文献类型：
--
作者：
W. Greene;W. Leonard;J. Depper;D. Nelson;T. Waldmann
人的白介素2受体(T细胞生长因子)在T细胞的生长中起着关键作用，是充分表达正常免疫反应所必需的。通过杂交瘤和重组DNA技术，对白介素2受体蛋白进行了生化鉴定和纯化，对其互补DNA的全长拷贝进行了分子克隆、测序并在真核细胞中进行了表达，并对受体基因进行了鉴定。白介素2受体基因的瞬时表达发生在正常的T细胞激活过程中，存在高亲和力和低亲和力的膜受体形式。一种自然产生的、可溶的受体也被分离出来，它在血清中的水平与各种疾病的活动性相关。人类嗜T淋巴细胞逆转录病毒I型和II型(HTLV-I和HTLV-II)产生的T细胞白血病中存在白介素2受体表达的失控，并与这些病毒的反式激活因子(Taf)基因的作用有关。针对白介素2受体的单抗正被用于治疗HTLV-I诱导的白血病和其他涉及激活的T细胞功能不正常的疾病。
The human receptor for interleukin-2 (T-cell growth factor) plays a critical role in the growth of T cells and is required for full expression of the normal immune response. Through hybridoma and recombinant DNA techniques, the interleukin-2 receptor protein has been biochemically characterized and purified; full-length copies of its complementary DNA have been molecularly cloned, sequenced, and expressed in eukaryotic cells; and the receptor gene has been characterized. Transient expression of the interleukin-2 receptor gene occurs during normal T-cell activation, and high- and low-affinity forms of the membrane receptor exist. A naturally occurring, soluble receptor has also been isolated, and its levels in serum correlate with the activity of various diseases. Deregulation of interleukin-2 receptor expression occurs in T-cell leukemias produced by the human T-lymphotropic retroviruses types I and II (HTLV-I and -II) and has been causally linked to the action of the trans-activator (taf) gene of these viruses. Monoclonal antibodies specific for the interleukin-2 receptor are being evaluated in the treatment of HTLV-I-induced leukemias and other conditions involving the inappropriate function of activated T cells.
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影响因子：
20.3
作者：
M. Krönke;J. Depper;W. Leonard;E. Vitetta;T. Waldmann;W. Greene
通讯作者：
M. Krönke;J. Depper;W. Leonard;E. Vitetta;T. Waldmann;W. Greene
影响因子：
56.9
作者：
CANTRELL, DA;SMITH, KA
通讯作者：
SMITH, KA
人 T 细胞白血病病毒 I 型长末端重复序列中顺式作用调节序列的位置。
DOI：
10.1073/pnas.82.19.6502
发表时间：
1985
影响因子：
11.1
作者：
Rosen,CA;Sodroski,JG;Haseltine,WA
通讯作者：
Haseltine,WA
HTLV-II 的反式激活基因诱导 IL-2 受体和 IL-2 细胞基因表达。
DOI：
10.1126/science.3010456
发表时间：
1986
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Greene,WC;Leonard,WJ;Wano,Y;Svetlik,PB;Peffer,NJ;Sodroski,JG;Rosen,CA;Goh,WC;Haseltine,WA
通讯作者：
Haseltine,WA