Getting under the skin: Social isolation and biological markers in the National Health and Aging Trends Study.
Getting under the skin: Social isolation and biological markers in the National Health and Aging Trends Study.
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DOI：
10.1111/jgs.17518
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发表时间：
2022-03
影响因子：
6.3
通讯作者：
Boyd CM
中科院分区：
文献类型：
--
作者：
Cudjoe TKM;Selvakumar S;Chung SE;Latkin CA;Roth DL;Thorpe RJ Jr;Boyd CM
与吸烟、高血压和久坐不动的生活方式等公认的危险因素相比，社会孤立是发病率和死亡率的危险因素。将社会孤立与发病率和死亡率联系起来的具体生物学机制仍不清楚。白细胞介素-6 （IL-6）和c反应蛋白（CRP）是炎症期间上调的生物标志物，随着年龄的增长，它们会对个体的健康产生长期的负面影响。利用国家健康与老龄化趋势研究（NHATS）的第7轮（2017）数据，我们研究了社会隔离与两种生物标志物：IL-6和高敏CRP之间的关系。本研究包括4648名65岁及以上的医疗保险受益人的全国代表性样本，他们使用干血斑（DBS）技术提供样本。我们使用多域类型学来定义社会隔离，该类型学考虑了生活安排、核心讨论网络、宗教出席和社会参与。通过NHATS第7轮收集的DBS获得IL-6和CRP。我们采用线性回归来检验社会隔离与生物标志物IL-6和CRP之间的关系。在调整了年龄、性别、种族/民族、收入、烟草使用、体重指数和慢性病后，我们发现严重的社会隔离和社会隔离与老年人中较高水平的IL-6和CRP值显著相关。社会隔离与较高水平的生物标志物（IL-6和CRP）有关。我们的研究结果揭示了社会孤立与老年人发病率和死亡率之间的关系。IL-6或CRP可能是未来临床和社会干预的近期结果测量，旨在改变社会隔离的轨迹及其相关的健康结果。
Social isolation is a risk factor for morbidity and mortality comparable to well-established risk factors including smoking, hypertension, and a sedentary lifestyle. The specific biological mechanisms that connect social isolation to morbidity and mortality remain unclear. Interleukin-6 (IL-6) and C-reactive protein (CRP) are biological markers that are upregulated during inflammation and can have long-term negative consequences for the health of individuals as they age. Utilizing Round 7 (2017) data from the National Health and Aging Trends Study (NHATS), we examine the relationship between social isolation and two biological markers: IL-6 and high-sensitivity CRP. This study included a nationally representative sample of 4648 Medicare beneficiaries 65 years and older who provided samples using dried blood spot (DBS) techniques. We defined social isolation utilizing a multi-domained typology that considers living arrangement, core discussion network, religious attendance, and social participation. IL-6 and CRP were obtained via DBS that were collected in Round 7 of the NHATS. We performed linear regression to examine the association between social isolation and biological markers IL-6 and CRP. After adjusting for age, gender, race/ethnicity, income, tobacco use, body mass index, and chronic conditions, we found that severe social isolation and social isolation were significantly associated with higher levels of IL-6 and CRP values among older adults. Social isolation is associated with higher levels of biological markers (IL-6 and CRP). Our findings inform the pathway between social isolation and morbidity and mortality among older adults. IL-6 or CRP could be a proximal outcome measures for future clinical and social interventions that seek to alter the trajectory of social isolation and its associated health outcomes.
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影响因子：
6.3
作者：
Giovannini S;Onder G;Liperoti R;Russo A;Carter C;Capoluongo E;Pahor M;Bernabei R;Landi F
通讯作者：
Landi F
DOI：
10.1093/geronb/gby037
发表时间：
2020-01-01
影响因子：
6.2
作者：
Cudjoe, Thomas K. M.;Roth, David L.;Thorpe, Roland J., Jr.
通讯作者：
Thorpe, Roland J., Jr.
影响因子：
5
作者：
BERKMAN, LF;SYME, SL
通讯作者：
SYME, SL
DOI：
10.1093/gerona/glv133
发表时间：
2015-11-01
影响因子：
5.1
作者：
Bandeen-Roche, Karen;Seplaki, Christopher L.;Kasper, Judith D.
通讯作者：
Kasper, Judith D.
影响因子：
6.1
作者：
Pecoits-Filho, R;Bárány, P;Stenvinkel, P
通讯作者：
Stenvinkel, P