Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections.
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections.
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DOI：
10.1038/s41467-021-21310-4
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发表时间：
2021-02-18
影响因子：
16.6
通讯作者：
Weber GF
中科院分区：
文献类型：
--
作者：
Bénard A;Jacobsen A;Brunner M;Krautz C;Klösch B;Swierzy I;Naschberger E;Podolska MJ;Kouhestani D;David P;Birkholz T;Castellanos I;Trufa D;Sirbu H;Vetter M;Kremer AE;Hildner K;Hecker A;Edinger F;Tenbusch M;Mühl-Zürbes P;Steinkasserer A;Richter E;Streeck H;Berger MM;Brenner T;Weigand MA;Swirski FK;Schett G;Grützmann R;Weber GF
严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）是一种全球性的健康威胁。在一项前瞻性多中心研究中，我们确定IL-3是SARS-CoV-2感染期间预后的独立预后标志物。具体而言，低血浆IL-3水平与SARS-CoV-2感染期间严重程度、病毒载量和死亡率增加有关。与非严重COVID-19患者相比，严重COVID-19患者还表现出循环浆细胞样树突状细胞（pDCs）减少，血浆IFNα和IFNλ水平较低。在肺部HSV-1感染的小鼠模型中，用重组IL-3治疗可降低病毒载量和死亡率。在机制上，IL-3通过刺激肺部CD123+上皮细胞分泌CXCL12，促进循环pDCs向气道募集，从而增强先天抗病毒免疫，这在小鼠和肺部疾病的COVID-19阴性患者中都是如此。本研究确定IL-3是SARS-CoV-2感染的预测性疾病标志物，也是肺部病毒感染的潜在治疗靶点。在这里，作者在一项多中心前瞻性研究中确定白细胞介素-3作为SARS-CoV-2感染严重程度和结果的预测标志物，并发现与非严重COVID-19患者相比，严重COVID-19患者的循环浆细胞样树突状细胞水平降低。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. In a prospective multicentric study, we identify IL-3 as an independent prognostic marker for the outcome during SARS-CoV-2 infections. Specifically, low plasma IL-3 levels is associated with increased severity, viral load, and mortality during SARS-CoV-2 infections. Patients with severe COVID-19 exhibit also reduced circulating plasmacytoid dendritic cells (pDCs) and low plasma IFNα and IFNλ levels when compared to non-severe COVID-19 patients. In a mouse model of pulmonary HSV-1 infection, treatment with recombinant IL-3 reduces viral load and mortality. Mechanistically, IL-3 increases innate antiviral immunity by promoting the recruitment of circulating pDCs into the airways by stimulating CXCL12 secretion from pulmonary CD123+ epithelial cells, both, in mice and in COVID-19 negative patients exhibiting pulmonary diseases. This study identifies IL-3 as a predictive disease marker for SARS-CoV-2 infections and as a potential therapeutic target for pulmunory viral infections. Here, the authors identify interleukin-3 as a predictive marker for severity and outcome of SARS-CoV-2 infection in a multi-center, prospective study and find that patients with severe COVID-19 have reduced circulating plasmacytoid dendritic cell levels compared to non-severe COVID-19 patients.
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影响因子：
4.4
作者：
Srivastava, Rupesh K.;Tomar, Geetanjali B.;Wani, Mohan R.
通讯作者：
Wani, Mohan R.
影响因子：
39
作者：
Wu, Chaomin;Chen, Xiaoyan;Song, Yuanlin
通讯作者：
Song, Yuanlin
影响因子：
--
作者：
PRELLNER, T;FLAMHOLC, L;WIDELL, A
通讯作者：
WIDELL, A
DOI：
10.1038/nri3865
发表时间：
2015-08
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Swiecki M;Colonna M
通讯作者：
Colonna M
影响因子：
38.9
作者：
Linssen, Catharina F. M.;Jacobs, Jan A.;Smismans, Annick
通讯作者：
Smismans, Annick