Anticancer activity of sea cucumber triterpene glycosides.
Anticancer activity of sea cucumber triterpene glycosides.
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DOI：
10.3390/md13031202
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发表时间：
2015-03-06
期刊：
影响因子：
5.4
通讯作者：
Kalinin VI
中科院分区：
文献类型：
--
作者：
Aminin DL;Menchinskaya ES;Pisliagin EA;Silchenko AS;Avilov SA;Kalinin VI
三萜皂苷是海参(海参总科，棘皮目)特有的次生代谢物。它们具有溶血、细胞毒、抗真菌等多种生物活性。这些天然产物在体外抑制多种人肿瘤细胞系的增殖，更重要的是，在啮齿动物体内注射一些海参三萜苷类的溶液可显著降低肿瘤负担和转移。其抗癌分子机制包括通过激活细胞内caspase死亡通路诱导肿瘤细胞凋亡，使细胞周期停滞在S或G2/M期，影响核因子和核转录因子-κB，以及上调某些参与癌变的细胞受体和酶，如表皮生长因子受体、蛋白激酶B、细胞外信号调节激酶、粘着斑激酶、基质金属蛋白酶-9等。给予某些糖苷类药物可减少癌细胞的黏附，抑制癌细胞的迁移和管状形成，抑制血管生成，抑制细胞增殖、集落形成和肿瘤侵袭。因此，在体外和体内，肿瘤的生长受到明显的抑制。一些海参三萜苷有可能作为P-gp介导的多药耐药逆转剂与标准细胞抑制剂联合治疗。
Triterpene glycosides are characteristic secondary metabolites of sea cucumbers (Holothurioidea, Echinodermata). They have hemolytic, cytotoxic, antifungal, and other biological activities caused by membranotropic action. These natural products suppress the proliferation of various human tumor cell lines in vitro and, more importantly, intraperitoneal administration in rodents of solutions of some sea cucumber triterpene glycosides significantly reduces both tumor burden and metastasis. The anticancer molecular mechanisms include the induction of tumor cell apoptosis through the activation of intracellular caspase cell death pathways, arrest of the cell cycle at S or G2/M phases, influence on nuclear factors, NF-κB, and up-down regulation of certain cellular receptors and enzymes participating in cancerogenesis, such as EGFR (epidermal growth factor receptor), Akt (protein kinase B), ERK (extracellular signal-regulated kinases), FAK (focal adhesion kinase), MMP-9 (matrix metalloproteinase-9) and others. Administration of some glycosides leads to a reduction of cancer cell adhesion, suppression of cell migration and tube formation in those cells, suppression of angiogenesis, inhibition of cell proliferation, colony formation and tumor invasion. As a result, marked growth inhibition of tumors occurs in vitro and in vivo. Some holothurian triterpene glycosides have the potential to be used as P-gp mediated MDR reversal agents in combined therapy with standard cytostatics.
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影响因子：
3.7
作者：
Attoub S;Arafat K;Gélaude A;Al Sultan MA;Bracke M;Collin P;Takahashi T;Adrian TE;De Wever O
通讯作者：
De Wever O
影响因子：
5.4
作者：
Bordbar S;Anwar F;Saari N
通讯作者：
Saari N
影响因子：
2.9
作者：
Liu, Bao-Shu;Yi, Yang-Hua;Wang, Zeng-Lei
通讯作者：
Wang, Zeng-Lei
影响因子：
5
作者：
Al Marzouqi, Nadia;Iratni, Rabah;Attoub, Samir
通讯作者：
Attoub, Samir
DOI：
10.1016/j.jsbmb.2006.06.022
发表时间：
2006-11-01
影响因子：
4.1
作者：
Kovalchuk, S. N.;Kozhemyako, V. B.;Aminin, D. L.
通讯作者：
Aminin, D. L.