Frontal White Matter Hyperintensities and Executive Functioning Performance in Older Adults.
Frontal White Matter Hyperintensities and Executive Functioning Performance in Older Adults.
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DOI：
10.3389/fnagi.2021.672535
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发表时间：
2021
影响因子：
4.8
通讯作者：
Woods AJ
中科院分区：
文献类型：
--
作者：
Boutzoukas EM;O'Shea A;Albizu A;Evangelista ND;Hausman HK;Kraft JN;Van Etten EJ;Bharadwaj PK;Smith SG;Song H;Porges EC;Hishaw A;DeKosky ST;Wu SS;Marsiske M;Alexander GE;Cohen R;Woods AJ
老年人的额叶结构比大多数其他大脑区域衰退得更快。额叶中的与脑损伤相关的变化与较差的执行功能有关（例如，工作记忆、转换/设置转换和抑制控制）。额叶白色高信号区（WMH）对正常老年人执行功能的影响和存在还相对未知。目前的研究评估了特定区域的额叶WMH负荷和认知性能之间的关系，在健康的老年人使用三个执行功能任务，从美国国立卫生研究院（NIHTB）认知电池。一组279名年龄在65-88岁的健康老年人完成了NIHTB和3 T T1加权和FLAIR MRI。病变分割可量化WMH体积并生成病变概率图。在FreeSurfer 6.0中将单个病变标测图配准到Desikan-Killiany图谱中，以定义感兴趣区域（ROI）。独立的线性回归评估执行功能性能和特定区域的WMH额叶ROI之间的关系。所有模型均包括年龄、性别、教育、估计的颅内总体积、多部位扫描仪差异和心血管疾病风险（使用Fragrance标准作为协变量）。在包括双侧上级额叶（左侧β = −0.18，FDR-p = 0.02;右侧β = −0.20，FDR-p = 0.01）和右侧内侧眶额（β = −0.17，FDR-p = 0.02）在内的三个额叶ROI中，POSTO移位表现与更大的WMH负荷相关。在一个额叶ROI中，右侧上级额叶（右侧β =-0.21，FDR-p = 0.01），与更高WMH负荷相关的电位抑制性能。工作记忆与额叶感兴趣区的WMH无显著相关。我们的研究表明，额叶WMH的位置和模式可能是重要的，以评估当检查年龄相关的认知功能的差异，涉及开关/设置转换和抑制。另一方面，工作记忆的表现是不相关的存在额WMH在这个样本中。这些数据表明，WMH可能会选择性地导致与年龄相关的执行功能下降。研究结果超出了已知与WMH存在相关的预测因素，包括年龄和心血管疾病风险。WMH在额叶内的扩散可能在认知老化的神经心理学特征中起关键作用。进一步的研究应探讨是否对可改变的血管因素或针对执行能力的认知干预的早期干预可能有助于减轻额叶WMH对执行功能的影响。
Frontal lobe structures decline faster than most other brain regions in older adults. Age-related change in the frontal lobe is associated with poorer executive function (e.g., working memory, switching/set-shifting, and inhibitory control). The effects and presence of frontal lobe white matter hyperintensities (WMH) on executive function in normal aging is relatively unknown. The current study assessed relationships between region-specific frontal WMH load and cognitive performance in healthy older adults using three executive function tasks from the NIH Toolbox (NIHTB) Cognition Battery. A cohort of 279 healthy older adults ages 65–88 completed NIHTB and 3T T1-weighted and FLAIR MRI. Lesion Segmentation Toolbox quantified WMH volume and generated lesion probability maps. Individual lesion maps were registered to the Desikan-Killiany atlas in FreeSurfer 6.0 to define regions of interest (ROI). Independent linear regressions assessed relationships between executive function performance and region-specific WMH in frontal lobe ROIs. All models included age, sex, education, estimated total intracranial volume, multi-site scanner differences, and cardiovascular disease risk using Framingham criteria as covariates. Poorer set-shifting performance was associated with greater WMH load in three frontal ROIs including bilateral superior frontal (left β = −0.18, FDR-p = 0.02; right β = −0.20, FDR-p = 0.01) and right medial orbitofrontal (β = −0.17, FDR-p = 0.02). Poorer inhibitory performance associated with higher WMH load in one frontal ROI, the right superior frontal (right β = −0.21, FDR-p = 0.01). There were no significant associations between working memory and WMH in frontal ROIs. Our study demonstrates that location and pattern of frontal WMH may be important to assess when examining age-related differences in cognitive functions involving switching/set-shifting and inhibition. On the other hand, working memory performance was not related to presence of frontal WMH in this sample. These data suggest that WMH may contribute selectively to age-related declines in executive function. Findings emerged beyond predictors known to be associated with WMH presence, including age and cardiovascular disease risk. The spread of WMH within the frontal lobes may play a key role in the neuropsychological profile of cognitive aging. Further research should explore whether early intervention on modifiable vascular factors or cognitive interventions targeted for executive abilities may help mitigate the effect of frontal WMH on executive function.
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影响因子：
2.6
作者：
Bolandzadeh N;Davis JC;Tam R;Handy TC;Liu-Ambrose T
通讯作者：
Liu-Ambrose T
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1080/13803395.2014.985636
发表时间：
2015-01-02
影响因子：
2.2
作者：
Cooley, Sarah A.;Cabeen, Ryan P.;Paul, Robert H.
通讯作者：
Paul, Robert H.
影响因子：
4.2
作者：
Carmichael, Owen;Mungas, Dan;Beckett, Laurel;Harvey, Danielle;Farias, Sarah Tomaszewski;Reed, Bruce;Olichney, John;Miller, Joshua;DeCarli, Charles
通讯作者：
DeCarli, Charles