Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan.
Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan.
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DOI：
10.1186/ar3547
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发表时间：
2011
影响因子：
4.9
通讯作者：
Tamakoshi K
中科院分区：
文献类型：
--
作者：
Muro Y;Sugiura K;Hoshino K;Akiyama M;Tamakoshi K
一些报告发现炎症性肌病的发作或活动表现出空间聚集性和季节性关联。我们最近在超过 20% 的皮肌炎患者中检测到针对黑色素瘤分化相关基因 5 (MDA-5) 的自身抗体。抗 MDA-5 抗体与临床无肌病性皮肌炎 (CADM) 中快速进展的间质性肺疾病的存在相关。本研究旨在评估日益增长的 CADM 患病率以及抗 MDA-5 阳性患者的地理发病率。我们查阅了病历并检查了 95 名患者（其中包括 36 名 CADM 患者）是否存在抗 MDA-5 抗体。血清采集自 1994 年至 2011 年。进行统计分析以评估 CADM 的发展和抗 MDA-5 抗体的存在是否与各种参数相关，包括发病年龄、发病季节、年度阳性率和居住城市人口。基于采集血清年份的三分位显示，在所有皮肌炎患者中，CADM 和抗 MDA-5 阳性患者有增加的趋势。 1994年至2010年，CADM和抗MDA-5抗体阳性患者的相对患病率显着增加。有趣的是，26 名患者体内的抗 MDA-5 抗体的存在与其居住城市的人口呈负相关。这是日本第一项调查抗 MDA-5 阳性皮肌炎表型分布的研究。这些表型发生率的区域差异表明，环境因素有助于产生针对 MDA-5 的抗体，从而引发先天抗病毒反应。
Several reports have found the onset or activity of inflammatory myopathies to show spatial clustering and seasonal association. We recently detected autoantibodies against melanoma differentiation-associated gene 5 (MDA-5) in more than 20% of patients with dermatomyositis. Anti-MDA-5 antibodies were associated with the presence of rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis (CADM). The present study aims to assess the growing prevalence of CADM and the geographical incidence of anti-MDA-5-positive patients. We reviewed medical charts and examined the presence of anti-MDA-5 antibodies in 95 patients, including 36 CADM patients. Sera were obtained from 1994 through 2011. Statistical analyses were performed to assess whether CADM development and the presence of anti-MDA-5 antibodies were associated with various parameters, including age at disease onset, season of onset, annual positivity, and population of resident city. Tertiles based on the year when the sera were collected showed increasing tendencies of CADM and anti-MDA-5-positive patients among all of the dermatomyositis patients. From 1994 to 2010, the relative prevalence of CADM and anti-MDA-5 antibody-positive patients significantly increased. Interestingly, the presence of anti-MDA-5 antibodies in 26 patients was inversely associated with the population of their city of residence. This is the first study to examine the distribution of anti-MDA-5-positive dermatomyositis phenotypes in Japan. Regional differences in the incidences of these phenotypes would suggest that environmental factors contribute to the production of antibodies against MDA-5, which triggers innate antiviral responses.
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影响因子：
--
作者：
Love, Lori A.;Weinberg, Clarice R.;McConnaughey, D. Robert;Oddis, Chester V.;Medsger, Thomas A., Jr.;Reveille, John D.;Arnett, Frank C.;Targoff, Ira N.;Miller, Frederick W.
通讯作者：
Miller, Frederick W.
影响因子：
6
作者：
Phillips, BA;Zilko, PJ;Mastaglia, FL
通讯作者：
Mastaglia, FL
影响因子：
5.1
作者：
Kobayashi, Ichiro;Okura, Yuka;Ariga, Tadashi
通讯作者：
Ariga, Tadashi
影响因子：
--
作者：
Hamaguchi, Yasuhito;Kuwana, Masataka;Fujimoto, Manabu
通讯作者：
Fujimoto, Manabu
影响因子：
--
作者：
Sato, S;Hirakata, M;Ikeda, Y
通讯作者：
Ikeda, Y