Ancient DNA reveals that the genetic structure of the northern Han Chinese was shaped prior to 3,000 years ago.
Ancient DNA reveals that the genetic structure of the northern Han Chinese was shaped prior to 3,000 years ago.
复制标题
古代DNA揭示北方汉人的基因结构早在3000年前就已经形成
DOI：
10.1371/journal.pone.0125676
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zhu H
中科院分区：
文献类型：
--
作者：
Zhao YB;Zhang Y;Zhang QC;Li HJ;Cui YQ;Xu Z;Jin L;Zhou H;Zhu H
汉族是世界上最大的民族，其起源、发展和扩张是复杂的。许多遗传学研究表明，汉族人可以分为两个截然不同的群体：北方汉族和南方汉族。中国南方汉族的遗传史已经得到了很好的研究。然而，北方汉族的遗传史仍然模糊不清。为了深入了解北方汉族的遗传史，从位于中原的横北遗址采集了89具人类遗骸，该遗址可以追溯到汉人崛起的关键过渡时期(约3000年前)。我们利用获得的线粒体DNA数据、衡北地区27个Y染色体SNP数据图谱，以及当代中国人和两个古代中国北方人的遗传数据，分析了衡北古人和现代北方汉族之间的关系。我们使用了广泛的群体遗传分析，包括主成分分析、共享的mtDNA单倍型分析和母体遗传距离的地理图谱。结果表明，衡北古人与今天的北方汉族有着很强的遗传相似性，在遗传上有别于今天的其他中国人和两个古老的人。这些发现表明，中国北方汉族的遗传结构在3000年前就已经在中原地区形成。
The Han Chinese are the largest ethnic group in the world, and their origins, development, and expansion are complex. Many genetic studies have shown that Han Chinese can be divided into two distinct groups: northern Han Chinese and southern Han Chinese. The genetic history of the southern Han Chinese has been well studied. However, the genetic history of the northern Han Chinese is still obscure. In order to gain insight into the genetic history of the northern Han Chinese, 89 human remains were sampled from the Hengbei site which is located in the Central Plain and dates back to a key transitional period during the rise of the Han Chinese (approximately 3,000 years ago). We used 64 authentic mtDNA data obtained in this study, 27 Y chromosome SNP data profiles from previously studied Hengbei samples, and genetic datasets of the current Chinese populations and two ancient northern Chinese populations to analyze the relationship between the ancient people of Hengbei and present-day northern Han Chinese. We used a wide range of population genetic analyses, including principal component analyses, shared mtDNA haplotype analyses, and geographic mapping of maternal genetic distances. The results show that the ancient people of Hengbei bore a strong genetic resemblance to present-day northern Han Chinese and were genetically distinct from other present-day Chinese populations and two ancient populations. These findings suggest that the genetic structure of northern Han Chinese was already shaped 3,000 years ago in the Central Plain area.
登录
查看更多内容
影响因子：
64.8
作者：
Lazaridis, Iosif;Patterson, Nick;Mittnik, Alissa;Renaud, Gabriel;Mallick, Swapan;Kirsanow, Karola;Sudmant, Peter H.;Schraiber, Joshua G.;Castellano, Sergi;Lipson, Mark;Berger, Bonnie;Economou, Christos;Bollongino, Ruth;Fu, Qiaomei;Bos, Kirsten I.;Nordenfelt, Susanne;Li, Heng;de Filippo, Cesare;Pruefer, Kay;Sawyer, Susanna;Posth, Cosimo;Haak, Wolfgang;Hallgren, Fredrik;Fornander, Elin;Rohland, Nadin;Delsate, Dominique;Francken, Michael;Guinet, Jean-Michel;Wahl, Joachim;Ayodo, George;Babiker, Hamza A.;Bailliet, Graciela;Balanovska, Elena;Balanovsky, Oleg;Barrantes, Ramiro;Bedoya, Gabriel;Ben-Ami, Haim;Bene, Judit;Berrada, Fouad;Bravi, Claudio M.;Brisighelli, Francesca;Busby, George B. J.;Cali, Francesco;Churnosov, Mikhail;Cole, David E. C.;Corach, Daniel;Damba, Larissa;van Driem, George;Dryomov, Stanislav;Dugoujon, Jean-Michel;Fedorova, Sardana A.;Romero, Irene Gallego;Gubina, Marina;Hammer, Michael;Henn, Brenna M.;Hervig, Tor;Hodoglugil, Ugur;Jha, Aashish R.;Karachanak-Yankova, Sena;Khusainova, Rita;Khusnutdinova, Elza;Kittles, Rick;Kivisild, Toomas;Klitz, William;Kucinskas, Vaidutis;Kushniarevich, Alena;Laredj, Leila;Litvinov, Sergey;Loukidis, Theologos;Mahley, Robert W.;Melegh, Bela;Metspalu, Ene;Molina, Julio;Mountain, Joanna;Nakkalajarvi, Klemetti;Nesheva, Desislava;Nyambo, Thomas;Osipova, Ludmila;Parik, Jueri;Platonov, Fedor;Posukh, Olga;Romano, Valentino;Rothhammer, Francisco;Rudan, Igor;Ruizbakiev, Ruslan;Sahakyan, Hovhannes;Sajantila, Antti;Salas, Antonio;Starikovskaya, Elena B.;Tarekegn, Ayele;Toncheva, Draga;Turdikulova, Shahlo;Uktveryte, Ingrida;Utevska, Olga;Vasquez, Rene;Villena, Mercedes;Voevoda, Mikhail;Winkler, Cheryl A.;Yepiskoposyan, Levon;Zalloua, Pierre;Zemunik, Tatijana;Cooper, Alan;Capelli, Cristian;Thomas, Mark G.;Ruiz-Linares, Andres;Tishkoff, Sarah A.;Singh, Lalji;Thangaraj, Kumarasamy;Villems, Richard;Comas, David;Sukernik, Rem;Metspalu, Mait;Meyer, Matthias;Eichler, Evan E.;Burger, Joachim;Slatkin, Montgomery;Paeaebo, Svante;Kelso, Janet;Reich, David;Krause, Johannes
通讯作者：
Krause, Johannes
影响因子：
5.3
作者：
Kong, QP;Yao, YG;Zhang, YP
通讯作者：
Zhang, YP
影响因子：
9.8
作者：
Keyser-Tracqui, C;Crubézy, E;Ludes, B
通讯作者：
Ludes, B
大规模 mtDNA 筛查揭示了东亚令人惊讶的母系复杂性及其对该地区人民的影响
影响因子：
10.7
作者：
Kong, Qing-Peng;Sun, Chang;Zhang, Ya-Ping
通讯作者：
Zhang, Ya-Ping
影响因子：
9.8
作者：
Oota, H;Saitou, N;Ueda, S
通讯作者：
Ueda, S