Microfluidics: a groundbreaking technology for PET tracer production?
Microfluidics: a groundbreaking technology for PET tracer production?
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微流体：一种用于宠物示踪剂生产的开创性技术？
DOI：
10.3390/molecules18077930
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发表时间：
2013-07-05
期刊：
影响因子：
--
通讯作者：
Wängler B
中科院分区：
文献类型：
--
作者：
Rensch C;Jackson A;Lindner S;Salvamoser R;Samper V;Riese S;Bartenstein P;Wängler C;Wängler B
近十年来，微流控技术在正电子发射断层扫描(PET)示踪剂合成中的应用引起了人们越来越大的兴趣。微流体的技术优势，特别是高表面体积比和由此产生的快速加热和冷却试剂的速度可以缩短反应时间，提高合成产率和减少副产物。此外，自动化反应优化、减少昂贵试剂的消耗以及减少系统足迹的途径已被成功证明。常规生产所需放射性水平的处理、在临床前和临床成像中使用微流控生产的PET示踪剂以及关于自辐射分解的可行性研究都取得了令人振奋的结果。然而，用于商业常规生产PET示踪剂的微流控合成器的数量非常有限。本研究综述了微流控PET示踪剂合成的最新进展，重点介绍了微流控PET示踪剂合成的关键设计方面、优势和弱点，并介绍了多样化的PET市场空间的几个特征，这些特征被认为对该领域的微流控器件的研究、开发和工程具有重要影响。此外，还讨论了批量和单剂生产、回旋加速器到质量控制集成以及集中和分散市场分配模型的主题。
Application of microfluidics to Positron Emission Tomography (PET) tracer synthesis has attracted increasing interest within the last decade. The technical advantages of microfluidics, in particular the high surface to volume ratio and resulting fast thermal heating and cooling rates of reagents can lead to reduced reaction times, increased synthesis yields and reduced by-products. In addition automated reaction optimization, reduced consumption of expensive reagents and a path towards a reduced system footprint have been successfully demonstrated. The processing of radioactivity levels required for routine production, use of microfluidic-produced PET tracer doses in preclinical and clinical imaging as well as feasibility studies on autoradiolytic decomposition have all given promising results. However, the number of microfluidic synthesizers utilized for commercial routine production of PET tracers is very limited. This study reviews the state of the art in microfluidic PET tracer synthesis, highlighting critical design aspects, strengths, weaknesses and presenting several characteristics of the diverse PET market space which are thought to have a significant impact on research, development and engineering of microfluidic devices in this field. Furthermore, the topics of batch- and single-dose production, cyclotron to quality control integration as well as centralized versus de-centralized market distribution models are addressed.
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影响因子：
7.3
作者：
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通讯作者：
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通讯作者：
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通讯作者：
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