q-space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy.
q-space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy.
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DOI：
10.1002/mrm.22389
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发表时间：
2010-05
影响因子：
3.3
通讯作者：
van Zijl, Peter C. M.
中科院分区：
文献类型：
--
作者：
Farrell, Jonathan A. D.;Zhang, Jiangyang;Jones, Melina V.;DeBoy, Cynthia A.;Hoffman, Paul N.;Landman, Bennett A.;Smith, Seth A.;Reich, Daniel S.;Calabresi, Peter A.;van Zijl, Peter C. M.
平行和垂直扩散性能的水在大鼠脊髓背根轴突切断术后3和30天，一个特定的侮辱导致早期轴突变性，随后在背柱白色物质（WM）髓鞘损伤。从q空间分析（即扩散概率密度函数，PDF）得到的结果与强扩散加权进行了比较，在低b值的常规各向异性和扩散率测量，以及轴突和髓鞘损伤的组织学。Q-空间对比度包括PDF的高度（PZERO）、半高全宽（FWHM）、均方根位移（RMSD）和峰度过剩（KE），其量化了与高斯扩散的偏差。轴突切断后，一个显着增加垂直扩散（KE减少）和减少平行扩散（KE增加）被发现在病变相对于未受伤的WM。值得注意的是，一个显着的变化，异常平行扩散检测到从3至30天的FWHM，但没有与传统的扩散。此外，方向FWHM和RMSD测量表现出不同的敏感性WM损伤。与组织学相比，垂直扩散的增加并不特异于脱髓鞘，而合并的平行扩散减少和垂直扩散增加与轴突损伤相关。
Parallel and perpendicular diffusion properties of water in the rat spinal cord were investigated 3 and 30 days after dorsal root axotomy, a specific insult resulting in early axonal degeneration followed by later myelin damage in the dorsal column white matter (WM). Results from q-space analysis (i.e. the diffusion probability density function, PDF) obtained with strong diffusion weighting were compared to conventional anisotropy and diffusivity measurements at low b-values, as well as to histology for axon and myelin damage. Q-space contrasts included the height (PZERO), full width at half maximum (FWHM), root mean square displacement (RMSD), and kurtosis excess (KE) of the PDF, which quantifies the deviation from Gaussian diffusion. Following axotomy, a significant increase in perpendicular diffusion (with decreased KE) and decrease in parallel diffusion (with increased KE) were found in lesions relative to uninjured WM. Notably, a significant change in abnormal parallel diffusion was detected from 3 to 30 days with FWHM, but not with conventional diffusivity. Also, directional FWHM and RMSD measurements exhibited different sensitivities to WM damage. When compared to histology, the increase in perpendicular diffusion was not specific to demyelination, whereas combined reduced parallel diffusion and increased perpendicular diffusion was associated with axon damage.
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