Entomological impact of mass administration of ivermectin and dihydroartemisinin-piperaquine in The Gambia: a cluster-randomized controlled trial.
Entomological impact of mass administration of ivermectin and dihydroartemisinin-piperaquine in The Gambia: a cluster-randomized controlled trial.
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DOI：
10.1186/s13071-022-05557-4
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发表时间：
2022-11-17
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
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撒哈拉以南非洲的病媒控制措施依赖驱虫蚊帐和室内滞留喷洒。杀虫剂的抗药性、干预措施的覆盖率低、蚊帐质量差和病媒行为的变化威胁到这些干预措施的有效性，因此需要替代工具。蚊子在吸食用伊维菌素（IVM）处理的人或动物后死亡。结合IVM进行大规模药物给药（MDA）可以减少病媒生存并减少疟疾传播。在一项以社区为基础的随机分组试验中评估了联合IVM和双氢青蒿素-哌喹的MDA对昆虫学的影响。2018年和2019年在冈比亚上游地区的32个村庄进行了一项随机分组试验。16个干预村庄的居民有资格在疟疾传播季节开始时每月接受三轮MDA。在每轮MDA后的7至14天内，用灯光诱捕器和人类登陆渔获物（HLC）进行昆虫学监测，然后每月进行一次，直到年底。通过直接膜摄食测定法测定IVM的杀蚊效果。在研究期间收集的15，017只蚊子中，99.65%（n = 14，965）为广义冈比亚按蚊（An. Gambiae S.L.），包括阿拉伯按蚊（56.2%）、科氏按蚊（24.5%）、狭义冈比亚按蚊（An. gemples.s.; 16.0%）和广义不死按蚊（An. funestus s.l.; 0.35%）。没有观察到干预措施对病媒奇偶性的影响。2019年，在干预村庄，通过光诱收集确定的媒介密度显著较低（调整后的发病率比：0.39; 95%置信区间[CI]：0.20，0.74; P = 0.005），但2018年并非如此。然而，在HLC收集确定的媒介密度是类似的干预和控制村。干预村昆虫接种率显著低于对照村（OR：0.36，95%CI：0.19，0.70; P = 0.003）。在给药后21天内，对接受IVM治疗的个体进行血液喂养时，苔藓虫病死亡率显著较高，特别是在成人和体重指数较高的个体中。大规模给药与IVM降低媒介密度和昆虫接种率，但对媒介奇偶性的影响不太清楚。从接受静脉注射药物治疗的个体采集的血液喂养的蚊子的存活率明显低于以对照组喂养的蚊子。宿主特性对蚊虫存活率的影响表明，剂量优化可以提高IVM效果。未来详细的昆虫学评价试验中，IVM作为独立的干预管理可能会阐明这种药物的贡献，观察到的减少传播。在线版本包含补充材料，可通过10.1186/s13071-022-05557-4获得。
Vector control interventions in sub-Saharan Africa rely on insecticide-treated nets and indoor residual spraying. Insecticide resistance, poor coverage of interventions, poor quality nets and changes in vector behavior threaten the effectiveness of these interventions and, consequently, alternative tools are needed. Mosquitoes die after feeding on humans or animals treated with ivermectin (IVM). Mass drug administration (MDA) with IVM could reduce vector survival and decrease malaria transmission. The entomological impact of MDA of combined IVM and dihydroartemisinin-piperaquine was assessed in a community-based, cluster-randomized trial. A cluster-randomized trial was implemented in 2018 and 2019 in 32 villages in the Upper River Region, The Gambia. The with the inhabitants of 16 intervention villages eligible to receive three monthly rounds of MDA at the beginning of the malaria transmission season. Entomological surveillance with light traps and human landing catches (HLC) was carried out during a 7- to 14-day period after each round of MDA, and then monthly until the end of the year. The mosquitocidal effect of IVM was determined by direct membrane feeding assays. Of the 15,017 mosquitoes collected during the study period, 99.65% (n = 14,965) were Anopheles gambiae sensu lato (An. gambiae s.l.), comprising Anopheles arabiensis (56.2%), Anopheles coluzzii (24.5%), Anopheles gambiae sensu stricto (An. gembiae s.s.; 16.0%) and Anopheles funestus sensu lato (An. funestus s.l.; 0.35%). No effect of the intervention on vector parity was observed. Vector density determined on light trap collections was significantly lower in the intervention villages in 2019 (adjusted incidence rate ratio: 0.39; 95% confidence interval [CI]: 0.20, 0.74; P = 0.005) but not in 2018. However, vector density determined in HLC collections was similar in both the intervention and control villages. The entomological inoculation rate was significantly lower in the intervention villages than in the control villages (odds ratio: 0.36, 95% CI: 0.19, 0.70; P = 0·003). Mosquito mortality was significantly higher when blood fed on IVM-treated individuals up to 21 days post-treatment, particularly in adults and individuals with a higher body mass index. Mass drug administration with IVM decreased vector density and the entomological inoculation rate while the effect on vector parity was less clear. Survival of mosquitoes fed on blood collected from IVM-treated individuals was significantly lower than that in mosquitoes which fed on controls. The influence of host characteristics on mosquito survivorship indicated that dose optimization could improve IVM efficacy. Future detailed entomological evaluation trials in which IVM is administered as stand-alone intervention may elucidate the contribution of this drug to the observed reduction in transmission. The online version contains supplementary material available at 10.1186/s13071-022-05557-4.
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影响因子：
3.2
作者：
Kenea O;Balkew M;Tekie H;Gebre-Michael T;Deressa W;Loha E;Lindtjørn B;Overgaard HJ
通讯作者：
Overgaard HJ
影响因子：
1.7
作者：
Dabira ED;Soumare HM;Lindsay SW;Conteh B;Ceesay F;Bradley J;Kositz C;Broekhuizen H;Kandeh B;Fehr AE;Nieto-Sanchez C;Ribera JM;Peeters Grietens K;Smit MR;Drakeley C;Bousema T;Achan J;D'Alessandro U
通讯作者：
D'Alessandro U
影响因子：
3
作者：
Cooke MK;Kahindi SC;Oriango RM;Owaga C;Ayoma E;Mabuka D;Nyangau D;Abel L;Atieno E;Awuor S;Drakeley C;Cox J;Stevenson J
通讯作者：
Stevenson J
影响因子：
4.9
作者：
Goncalves, Bronner P.;Pett, Helmi;ter Heine, Rob
通讯作者：
ter Heine, Rob
影响因子：
3.7
作者：
Ceesay, Serign J.;Casals-Pascual, Climent;Conway, David J.
通讯作者：
Conway, David J.