An update and systematic review on drug therapies for the treatment of refractory chronic cough.
An update and systematic review on drug therapies for the treatment of refractory chronic cough.
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DOI：
10.1080/14656566.2018.1462795
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发表时间：
2018-05
影响因子：
3.2
通讯作者：
Birring SS
中科院分区：
文献类型：
--
作者：
Ryan NM;Vertigan AE;Birring SS
前言：慢性咳嗽(CC)很常见，常伴有严重的合并症和生活质量下降。在多达50%的病例中，尽管进行了广泛的调查和治疗试验，但咳嗽仍是难治性的。难治性CC的关键异常可能是感觉神经功能障碍，类似于喉过敏和神经病理性疼痛。涵盖的领域：这项系统性综述的目的是评估难治性CC的药物疗法。作者回顾了目前CC的治疗，并讨论了神经病理性疼痛和难治性CC之间的相似之处。他们回顾了改变用途和新的药理治疗方法。在可能的情况下，进行了几项荟萃分析来比较治疗的效果。专家评论：加巴喷丁和普瑞巴林等止痛药用途不同，可减少咳嗽次数，提高生活质量。与语音病理学一样，它们也是难治性CC的重要替代治疗方法。然而，还需要更多的治疗，其中最有希望的是P2X3离子通道受体拮抗剂。随着更好地了解神经元的激活和敏化及其在大脑中的信号处理，改进的咳嗽动物模型，以及有效的咳嗽测量工具的使用，将开发出更有效的治疗方法。
Introduction: Chronic Cough (CC) is common and often associated with significant comorbidity and decreased quality of life. In up to 50% of cases, the cough is refractory despite extensive investigation and treatment trials. It is likely that the key abnormality in refractory CC is dysfunctional, hypersensitive sensory nerves, similar to conditions such as laryngeal hypersensitivity and neuropathic pain. Areas covered: The aim of this systematic review is to assess drug therapies for refractory CC. The authors review the current management of CC and provide discussion of the similarities between neuropathic pain and refractory CC. They review repurposed and new pharmacological treatments. Several meta-analyses were performed to compare the efficacy of treatments where possible. Expert opinion: Repurposed pain medications such as gabapentin and pregabalin reduce the frequency of cough and improve quality of life. Along with speech pathology, they are important and alternate treatments for refractory CC. However, more treatments are needed and the P2X3 ion channel receptor antagonists show the most promise. With a better understanding of neuronal activation and sensitisation and their signal processing in the brain, improved animal models of cough, and the use of validated cough measurement tools, more effective treatments will develop.
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DOI：
10.1152/ajpregu.00862.2005
发表时间：
2006-08-01
影响因子：
2.8
作者：
Canning, Brendan J.;Farmer, David G.;Mori, Nanako
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DOI：
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DOI：
10.1152/physiol.00026.2008
发表时间：
2008-12
期刊：
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影响因子：
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作者：
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