Multi-Modal and Targeted Imaging Improves Automated Mid-Brain Segmentation.
Multi-Modal and Targeted Imaging Improves Automated Mid-Brain Segmentation.
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多模态和靶向成像改善了自动化中脑分割。
DOI：
10.1117/12.2254428
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Landman,BennettA
中科院分区：
文献类型：
--
作者：
Plassard,AndrewJ;D'Haese,PierreF;Pallavaram,Srivatsan;Newton,AllenT;Claassen,DanielO;Dawant,BenoitM;Landman,BennettA
The basal ganglia and limbic system, particularly the thalamus, putamen, internal and external globus pallidus, substantia nigra, and sub-thalamic nucleus, comprise a clinically relevant signal network for Parkinson’s disease. In order to manually trace these structures, a combination of high-resolution and specialized sequences at 7T are used, but it is not feasible to scan clinical patients in those scanners. Targeted imaging sequences at 3T such as F-GATIR, and other optimized inversion recovery sequences, have been presented which enhance contrast in a select group of these structures. In this work, we show that a series of atlases generated at 7T can be used to accurately segment these structures at 3T using a combination of standard and optimized imaging sequences, though no one approach provided the best result across all structures. In the thalamus and putamen, a median Dice coefficient over 0.88 and a mean surface distance less than 1.0mm was achieved using a combination of T1 and an optimized inversion recovery imaging sequences. In the internal and external globus pallidus a Dice over 0.75 and a mean surface distance less than 1.2mm was achieved using a combination of T1 and FGATIR imaging sequences. In the substantia nigra and sub-thalamic nucleus a Dice coefficient of over 0.6 and a mean surface distance of less than 1.0mm was achieved using the optimized inversion recovery imaging sequence. On average, using T1 and optimized inversion recovery together produced significantly improved segmentation results than any individual modality (p<0.05 wilcox sign-rank test).
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胎鼠肝器官培养物合成的生长调节素（胰岛素样生长因子）的表征。
影响因子：
4.8
作者：
M. Rechler;H. Eisen;O. Higa;P. Nissley;A. Moses;E. Schilling;I. Fennoy;C. Bruni;L. Phillips;K. Baird
通讯作者：
K. Baird
DOI：
10.1016/s0021-9258(18)32085-4
发表时间：
1983-07
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
K. Heidenreich;N. Zahniser;P. Berhanu;D. Brandenburg;J. Olefsky
通讯作者：
K. Heidenreich;N. Zahniser;P. Berhanu;D. Brandenburg;J. Olefsky
比较胰岛素和胰岛素样生长因子 I 在小鼠乳腺上皮细胞酪蛋白基因表达以及 α-乳清蛋白和葡萄糖转运活性发展中的作用。
影响因子：
4.8
作者：
C. Prosser;Lakshmanan Sankaran;Lothar Hennighausen;Yale J. Topper
通讯作者：
Yale J. Topper
DOI：
10.1016/s0021-9258(18)34631-3
发表时间：
1982-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
J. Massagué;M. Czech
通讯作者：
J. Massagué;M. Czech
影响因子：
3.5
作者：
H. Tucker
通讯作者：
H. Tucker