Overexpression of miR-210-3p Impairs Extravillous Trophoblast Functions Associated with Uterine Spiral Artery Remodeling.
Overexpression of miR-210-3p Impairs Extravillous Trophoblast Functions Associated with Uterine Spiral Artery Remodeling.
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miR-210- 3 p过表达损害与子宫螺旋动脉重塑相关的绒毛外滋养细胞功能
DOI：
10.3390/ijms22083961
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发表时间：
2021-04-12
影响因子：
5.6
通讯作者：
Peng C
中科院分区：
文献类型：
--
作者：
Hayder H;Fu G;Nadeem L;O'Brien JA;Lye SJ;Peng C
Hsa-miR-210-3p has been reported to be upregulated in preeclampsia (PE); however, the functions of miR-210-3p in placental development are not fully understood, and, consequently, miR-210-3p’s role in the pathogenesis of PE is still under investigation. In this study, we found that overexpression of miR-210-3p reduced trophoblast migration and invasion, extravillous trophoblast (EVT) outgrowth in first trimester explants, expression of endovascular trophoblast (enEVT) markers and the ability of trophoblast to form endothelial-like networks. In addition, miR-210-3p overexpression significantly downregulated the mRNA levels of interleukin-1B and -8, as well as CXC motif ligand 1. These cytokines have been suggested to play a role in EVT invasion and the recruitment of immune cells to the spiral artery remodeling sites. We also showed that caudal-related homeobox transcription factor 2 (CDX2) is targeted by miR-210-3p and that CDX2 downregulation mimicked the observed effects of miR-210-3p upregulation in trophoblasts. These findings suggest that miR-210-3p may play a role in regulating events associated with enEVT functions and its overexpression could impair spiral artery remodeling, thereby contributing to PE.
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影响因子：
2.8
作者：
Huppertz B
通讯作者：
Huppertz B
影响因子：
3.6
作者：
Hess, A. P.;Hamilton, A. E.;Giudice, L. C.
通讯作者：
Giudice, L. C.
影响因子：
12.4
作者：
Brkic, Jelena;Dunk, Caroline;Peng, Chun
通讯作者：
Peng, Chun
影响因子：
--
作者：
Jia, Rui-Zhe;Ding, Gui-Chun;Lu, Qin
通讯作者：
Lu, Qin
影响因子：
2.9
作者：
Enquobahrie, Daniel A.;Hensley, Mark;Williams, Michelle A.
通讯作者：
Williams, Michelle A.