The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia.
The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia.
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DOI：
10.2174/1389201019666180427110547
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发表时间：
2018
影响因子：
2.8
通讯作者：
Huppertz B
中科院分区：
文献类型：
--
作者：
Huppertz B
妊娠病理先兆子痫仍然是孕产妇和围产期发病率和死亡率的主要原因之一。与此同时，其病因远未确定，在许多方面仍不清楚。一些假设已经发展，以解释胎盘和母亲之间的相互作用改变导致子痫前期的临床症状。然而，它们都没有提供机会来解释迟发性与早发性、轻度与重度以及有无额外胎儿生长限制的病例差异。本文指出了目前最重要的假设的不足之处，同时提出了一套新的解释，包括母体易感性，绒毛/外绒毛滋养细胞分化，以解释先兆子痫的发生。这样的阐明允许遵循新的科学路线和途径来解开先兆子痫的病因。
The pregnancy pathology preeclampsia is still among the leading causes of ma-ternal and perinatal morbidity and mortality. At the same time, its etiology is far from being identified and remains obscure in a number of facets. A number of hypotheses have been developed to explain the altered interplay between placenta and mother leading to the clinical symptoms of preeclampsia. However, none of them offers the opportunity to explain the variability of cases with late-onset versus early-onset, mild versus severe and with or with-out additional fetal growth restriction. This paper identifies the weaknesses of the most important current hypothesis and at the same time offers a set of new elucidations including maternal susceptibility, and villous/extravillous trophoblast differentiation to explain the development of preeclampsia. Such elucidations allow following new scientific routes and pathways to untangle the etiology of preeclampsia.
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影响因子：
2.3
作者：
Moser G;Weiss G;Sundl M;Gauster M;Siwetz M;Lang-Olip I;Huppertz B
通讯作者：
Huppertz B
影响因子：
3.8
作者：
Huppertz, B.
通讯作者：
Huppertz, B.
影响因子：
2
作者：
Kawamura, Takakazu;Kakogawa, Jun;Kanayama, Naohiro
通讯作者：
Kanayama, Naohiro
影响因子：
6.1
作者：
Moser, G.;Gauster, M.;Huppertz, B.
通讯作者：
Huppertz, B.
影响因子：
6
作者：
Jauniaux, E;Watson, AL;Burton, GJ
通讯作者：
Burton, GJ