Effect of Modified Formula Radix Hedysari on the Amplification Effect during Peripheral Nerve Regeneration.
Effect of Modified Formula Radix Hedysari on the Amplification Effect during Peripheral Nerve Regeneration.
复制标题
加减方红芪对周围神经再生放大效应的影响
DOI：
10.1155/2013/647982
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Jiang BG
中科院分区：
文献类型：
--
作者：
Wang ZY;Zhang PX;Han N;Kou YH;Yin XF;Jiang BG
许多研究表明，神经再生过程中存在代偿性放大现象。当一条相对较细的神经被用作供体，在切断后与远端神经连接时，供体神经再生的侧支比其自身纤维多，这些侧支延伸到远端残端，长入远端神经内膜管，最终到达并支配靶器官。这就是所谓的放大现象。在本研究中，我们观察了加味红景天(MFRH)作为辅助治疗12周的大鼠的扩增现象。将大鼠随机分为3组(每组6只)。模型组和治疗组以腓总神经近端作为供神经，与胫骨远端神经相连。正常组大鼠不做手术。术后治疗组给予MFRH系统治疗，模型组和正常组不给予治疗。结果表明，治疗组神经传导速度、纤维直径、轴突直径、再生神经纤维数、放大倍数均优于模型组，提示MFRH具有促进神经放大作用。
Many studies have demonstrated a compensatory amplification phenomenon during nerve regeneration. When a relatively fine nerve is used as a donor to connect to a distal nerve after transection, the donor nerve regenerates more collaterals than its own fibers, which extend to the distal stump, grow into distal endoneurial tubes, and finally reach and dominate the target organs. This is known as the amplification phenomenon. In this study, we investigated the amplification phenomenon in rats treated with Modified Formula Radix Hedysari (MFRH) as adjuvant therapy for 12 weeks. The rats were divided into three groups at random (six animals in each group). In the model group and the treatment group, the proximal common peroneal nerve was used as a donor nerve to connect to the distal tibial nerve. Rats in the normal group did not undergo surgery. After surgery, the treatment group was administered MFRH as systemic therapy, while the model group and the normal group were not given treatment. The results demonstrated that the nerve conduction velocity, the fiber diameter, the axon diameter, the number of regenerating nerve fibers, and the amplification ratio were better in the treatment group than in the model group, suggesting that MFRH promoted the nerve amplification effect.
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影响因子：
9.3
作者：
Ydens E;Cauwels A;Asselbergh B;Goethals S;Peeraer L;Lornet G;Almeida-Souza L;Van Ginderachter JA;Timmerman V;Janssens S
通讯作者：
Janssens S
影响因子：
3.1
作者：
Ikeda, Masayoshi;Oka, Yoshinori
通讯作者：
Oka, Yoshinori
运动通路卒中后皮质脊髓束华勒变性的纵向扩散张量成像研究
影响因子：
5.7
作者：
Yu, Chunshui;Zhu, Chaozhe;Li, Kuncheng
通讯作者：
Li, Kuncheng
DOI：
10.1679/aohc.46.243
发表时间：
1983-01-01
期刊：
ARCHIVUM HISTOLOGICUM JAPONICUM
影响因子：
--
作者：
IDE, C
通讯作者：
IDE, C
影响因子：
5.4
作者：
Wei, Shaoyin;Yin, Xiaofeng;Jiang, Baoguo
通讯作者：
Jiang, Baoguo