Priming of protective T cell responses against virus-induced tumors in mice with human immune system components.
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components.
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DOI：
10.1084/jem.20081720
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发表时间：
2009-06-08
期刊：
影响因子：
--
通讯作者：
Münz C
中科院分区：
文献类型：
--
作者：
Strowig T;Gurer C;Ploss A;Liu YF;Arrey F;Sashihara J;Koo G;Rice CM;Young JW;Chadburn A;Cohen JI;Münz C
Many pathogens that cause human disease infect only humans. To identify the mechanisms of immune protection against these pathogens and also to evaluate promising vaccine candidates, a small animal model would be desirable. We demonstrate that primary T cell responses in mice with reconstituted human immune system components control infection with the oncogenic and persistent Epstein-Barr virus (EBV). These cytotoxic and interferon-γ–producing T cell responses were human leukocyte antigen (HLA) restricted and specific for EBV-derived peptides. In HLA-A2 transgenic animals and similar to human EBV carriers, T cell responses against lytic EBV antigens dominated over recognition of latent EBV antigens. T cell depletion resulted in elevated viral loads and emergence of EBV-associated lymphoproliferative disease. Both loss of CD4+ and CD8+ T cells abolished immune control. Therefore, this mouse model recapitulates features of symptomatic primary EBV infection and generates T cell–mediated immune control that resists oncogenic transformation.
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