Duration of antibody responses following severe acute respiratory syndrome coronavirus 2 infection.
Duration of antibody responses following severe acute respiratory syndrome coronavirus 2 infection.
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严重急性呼吸综合征冠状病毒 2 感染后抗体反应的持续时间
DOI：
10.1007/s11845-021-02860-4
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发表时间：
2022-12
影响因子：
2.1
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Jiang Y;Wei X;Wang H;Li G
关于SARS冠状病毒2型（SARS-CoV-2）感染后患者体内抗SARS-CoV-2免疫球蛋白G（IgG）抗体的持续时间知之甚少。我们的目的是确定SARS-CoV-2感染后免疫球蛋白G（IgG）和M（IgM）抗体应答的持续时间，并评估短期抗SARS-CoV-2 IgG的危险因素。我们测量了94名从SARS-CoV-2感染中恢复的患者的抗体应答。采用卡方检验和多因素Logistic回归分析确定短期（< 6个月）抗SARS-CoV-2 IgG的危险因素。IgG抗体检测在所有患者，直到4个月，19（21.8%）恢复期患者恢复到IgG阴性4-6个月后症状发作。IgM抗体在症状发作后4-6个月显著下降至5.7%。患者特征与可检测IgG的持续时间短无关。相当一部分康复者在SARS-CoV-2感染后可能表现出短暂的IgG应答。我们的研究结果表明，从SARS-CoV-2感染中恢复的患者，如果他们的抗SARS-CoV-2 IgG抗体检测不到，也应该接种疫苗。
Little is known on the duration of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibodies in patients following SARS-CoV-2 infection. We aimed to determine the duration of the immunoglobulin G (IgG) and M (IgM) antibody responses following SARS-CoV-2 infection and to evaluate the risk factors for a short duration of anti-SARS-CoV-2 IgG. We measured antibody responses in 94 patients who had recovered from SARS-CoV-2 infection. The chi-square test and multivariable logistic regression analysis were used to identify risk factors for a short duration (< 6 months) of anti-SARS-CoV-2 IgG. IgG antibodies were detectable in all patients until 4 months; 19 (21.8%) convalescent patients reverted to IgG negative 4–6 months after symptom onset. IgM antibodies decreased significantly to 5.7% at 4–6 months after symptom onset. Patient characteristics were not associated with a short duration of detectable IgG. A substantial fraction of convalescents may exhibit a transient IgG response following SARS-CoV-2 infection. Our findings suggest that patients who have recovered from SARS-CoV-2 infection should also be vaccinated if their anti-SARS-CoV-2 IgG antibodies are undetectable.
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