The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions.
The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions.
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DOI：
10.3389/fnbeh.2020.601939
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发表时间：
2020
影响因子：
3
通讯作者：
Handa RJ
中科院分区：
文献类型：
--
作者：
Sheng JA;Bales NJ;Myers SA;Bautista AI;Roueinfar M;Hale TM;Handa RJ
下丘脑-垂体-肾上腺轴是一个复杂的神经内分泌通路和反馈回路系统，其功能是维持生理稳态。下丘脑-垂体-肾上腺（HPA）轴的异常发育可进一步导致中枢神经系统中神经肽和神经递质合成以及外周糖皮质激素合成的长期改变。总之，这些变化可能会导致成年期神经内分泌、行为、自主神经和代谢功能的破坏。本文就HPA轴的调控及其发展作一综述。我们还将研究母胎下丘脑-垂体-肾上腺轴和正常胎儿环境的破坏，这成为成年期许多神经发育病理学的主要危险因素，如重度抑郁症，焦虑症，精神分裂症等。
The hypothalamic-pituitary-adrenal axis is a complex system of neuroendocrine pathways and feedback loops that function to maintain physiological homeostasis. Abnormal development of the hypothalamic-pituitary-adrenal (HPA) axis can further result in long-term alterations in neuropeptide and neurotransmitter synthesis in the central nervous system, as well as glucocorticoid hormone synthesis in the periphery. Together, these changes can potentially lead to a disruption in neuroendocrine, behavioral, autonomic, and metabolic functions in adulthood. In this review, we will discuss the regulation of the HPA axis and its development. We will also examine the maternal-fetal hypothalamic-pituitary-adrenal axis and disruption of the normal fetal environment which becomes a major risk factor for many neurodevelopmental pathologies in adulthood, such as major depressive disorder, anxiety, schizophrenia, and others.
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DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
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影响因子：
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影响因子：
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