Potential role of carotenoids as antioxidants in human health and disease.
Potential role of carotenoids as antioxidants in human health and disease.
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DOI：
10.3390/nu6020466
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发表时间：
2014-01-27
期刊：
影响因子：
5.9
通讯作者：
Burda K
中科院分区：
文献类型：
--
作者：
Fiedor J;Burda K
类胡萝卜素是一类普遍存在的类异戊二烯色素。它们是单线态氧的非常有效的物理猝灭剂和其它活性氧物质的清除剂。类胡萝卜素也可以作为化学猝灭剂进行不可逆的氧化。这些反应背后的分子机制仍然没有完全了解，特别是在类胡萝卜素的抗氧化和促氧化活性的背景下，类胡萝卜素虽然不是由人类和动物合成的，但也存在于他们的血液和组织中，有助于许多生化过程。类胡萝卜素的抗氧化潜力对人类健康特别重要，因为失去抗氧化剂-活性氧平衡会导致“氧化应激”，这是各种慢性疾病的致病过程的关键因素。来自流行病学研究和临床试验的数据强烈支持这样的观察，即适当的类胡萝卜素补充剂可以显着降低由活性氧介导的几种疾病的风险。在这里，我们想强调膳食类胡萝卜素摄入在典型的广泛的现代文明疾病中的有益（保护）作用，即，癌症、心血管疾病或光敏性疾病，在类胡萝卜素独特的抗氧化特性的背景下。
Carotenoids constitute a ubiquitous group of isoprenoid pigments. They are very efficient physical quenchers of singlet oxygen and scavengers of other reactive oxygen species. Carotenoids can also act as chemical quenchers undergoing irreversible oxygenation. The molecular mechanisms underlying these reactions are still not fully understood, especially in the context of the anti- and pro-oxidant activity of carotenoids, which, although not synthesized by humans and animals, are also present in their blood and tissues, contributing to a number of biochemical processes. The antioxidant potential of carotenoids is of particular significance to human health, due to the fact that losing antioxidant-reactive oxygen species balance results in “oxidative stress”, a critical factor of the pathogenic processes of various chronic disorders. Data coming from epidemiological studies and clinical trials strongly support the observation that adequate carotenoid supplementation may significantly reduce the risk of several disorders mediated by reactive oxygen species. Here, we would like to highlight the beneficial (protective) effects of dietary carotenoid intake in exemplary widespread modern civilization diseases, i.e., cancer, cardiovascular or photosensitivity disorders, in the context of carotenoids’ unique antioxidative properties.
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影响因子：
3.5
作者：
Böhm, F;Edge, R;Truscott, TG
通讯作者：
Truscott, TG
类胡萝卜素在心脏健康中的动态作用。
DOI：
10.3390/molecules17044755
发表时间：
2012-04-23
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Agarwal M;Parameswari RP;Vasanthi HR;Das DK
通讯作者：
Das DK
影响因子：
3.5
作者：
Burke, M;Edge, R;Truscott, TG
通讯作者：
Truscott, TG
影响因子：
1.8
作者：
Castenmiller, JJM;West, CE
通讯作者：
West, CE
DOI：
10.1034/j.1600-0781.2003.00044.x
发表时间：
2003-08-01
影响因子：
2.6
作者：
Césarini, JP;Michel, L;Béjot, M
通讯作者：
Béjot, M