Dynamics of phase-independent spectro-temporal tuning in primary auditory cortex of the awake ferret.
Dynamics of phase-independent spectro-temporal tuning in primary auditory cortex of the awake ferret.
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DOI：
10.1016/j.neuroscience.2012.04.029
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发表时间：
2012-07-12
期刊：
影响因子：
3.3
通讯作者：
Shechter, B.
中科院分区：
文献类型：
--
作者：
Depireux, D. A.;Dobbins, H. D.;Marvit, P.;Shechter, B.
关键词：
皮层神经元的调节通常作为静态属性或在稳态状态下进行测量，尽管许多研究表明调节取决于神经元响应期间测量的时间（例如，起始、持续和偏移）。我们之前已经表明，对特征瞬态的锁相调谐从声音开始就演变为动态量。在这项后续研究中，我们检查了特征瞬态期间的相位独立调谐。根据之前的结果，我们假设相位无关调谐应该与锁相调谐在相同的时间尺度上发展。我们使用恒定电平的刺激，但在平坦的频谱时间包络和具有明确定义的频谱密度和时间周期性的调制包络之间交替，这允许测量新的频谱时间内容的调谐变化，就像在运行语音和其他快速过渡的声音期间发生的那样，而不会出现令人困惑的声级变化。对于 95% 的神经元来说，在反应过程中，调节从一开始就发生了显着变化。对于大多数细胞来说，变化发生在特征出现后的前 40 毫秒内，通常甚至在 10-20 毫秒左右。这巩固了这样的想法：调优可以从开始调优快速转变为持续的稳态调优。
Tuning of cortical neurons is often measured as a static property, or during a steady-state regime, despite a number of studies suggesting that tuning depends on when it is meaured during a neuron’s response (e.g., onset vs. sustained vs. offset). We have previously shown that phase-locked tuning to feature transients evolves as a dynamic quantity from the onset of the sound. In this follow-up study, we examined the phase-indepenent tuning during feature transients. Based on previous results, we hypothesized phase-independent tuning should evolve on the same timescale as phase-locked tuning. We used stimuli of constant level, but alternating between flat spectro-temporal envelope and a modulated envelope with well defined spectral density and temporal periodicity This allowed the measure of changes in tuning to novel spectro-temporal content, as happens during running speech and other sounds with rapid transitions without a confounding change in sound level. For 95% of neurons, tuning changed significantly from the onset, over the course of the response. For a majority of these cells, the change occurred within the first 40 ms following a feature onset, often even around 10–20ms. This solidifies the idea that tuning can change rapidly from onset tuning to the sustained, steady-state tuning.
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DOI：
10.1073/pnas.022638499
发表时间：
2002-02-05
影响因子：
11.1
作者：
Mazer, JA;Vinje, WE;Gallant, JL
通讯作者：
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影响因子：
2.9
作者：
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通讯作者：
Sato, Y
影响因子：
2.4
作者：
EGGERMONT, JJ
通讯作者：
EGGERMONT, JJ
影响因子：
56.9
作者：
deCharms, RC;Blake, DT;Merzenich, MM
通讯作者：
Merzenich, MM
影响因子：
3
作者：
Dobbins, Heather D.;Marvit, Peter;Depireux, Didier A.
通讯作者：
Depireux, Didier A.