Zonulin, as a marker of intestinal permeability, is elevated in IgA nephropathy and IgA vasculitis with nephritis.
Zonulin, as a marker of intestinal permeability, is elevated in IgA nephropathy and IgA vasculitis with nephritis.
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Zonulin作为肠通透性的标志，在IgA肾病和IgA血管炎伴肾炎时升高。
DOI：
10.1093/ckj/sfac214
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发表时间：
2023-01
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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免疫球蛋白A肾病(IgAN)和IgA血管炎合并肾炎(IgAV-N)被认为是相关疾病，具有相似的临床病理表型。循环半乳糖缺陷型IgA1(Gd-IgA1)免疫复合物和粘膜免疫升高与IgAN和IgAV-N的发病有关。最近，研究发现，作为肠道通透性调节因子的带状蛋白在一些炎症性和自身免疫相关疾病中显著升高。然而，zonlin是否也在IgAN和IgAV-N中起作用尚不清楚。采用双抗体夹心酶联免疫吸附试验检测73例IgAV-N患者、68例IgAN患者和54例健康对照的血中带状蛋白和Gd-IgA1水平。用受试者工作特征曲线下面积(AUC)和综合判别率改进(IDI)分析评价Zonlin和Gd-IgA1联合检测的诊断效率。与健康对照组比较，IgAV-N组和IgAN组的带蛋白和Gd-IgA1水平均显著升高(P<0.01)。此外，与IgAN患者相比，IgAV-N患者的循环zonrin水平更高(P=4.020)。在诊断IgAN和IgAV-N时，在Gd-Ig A1中加入带状球蛋白显示出比单独Gd-Ig A1更好的预测性能，如显著增加的AUC(Ig AN：0.805比0.708，P=0.0021；Ig AV-N：0.886比0.673，P<0.01)和显著的IDI(Ig AN：IDI 0.136，P<0.01；Ig A V-N：Idi 0.281，P<0.01)。在IgAV-N和IgAN患者中均检测到循环带状蛋白水平升高。建议联合检测循环带状蛋白和Gd-IgA1作为诊断IgAV-N和IgAN的无创性生物标志物。
Immunoglobulin A nephropathy (IgAN) and IgA vasculitis with nephritis (IgAV-N) are considered related diseases and share some similar clinicopathologic phenotypes. Elevated circulating galactose-deficient IgA1 (Gd-IgA1)-containing immune complexes and mucosal immunity were associated with the pathogenesis of IgAN and IgAV-N. Recently, studies have identified that the zonulin level, as a modulator of intestinal permeability, is significantly elevated in several inflammatory and autoimmune-related diseases. However, whether zonulin also plays a role in IgAN and IgAV-N is not clear. A total of 73 IgAV-N patients, 68 IgAN patients and 54 healthy controls were assessed for circulating zonulin and Gd-IgA1 levels by enzyme-linked immunosorbent assay. The diagnostic efficiency of the combination of zonulin with Gd-IgA1 was evaluated by the area under the receiver operating characteristic curve (AUC) and integrated discrimination improvement (IDI) analysis. Compared with healthy controls, we found that both IgAV-N and IgAN patients had elevated zonulin and Gd-IgA1 levels (P < .001). Additionally, patients with IgAV-N presented with even higher circulating zonulin levels than patients with IgAN (P = .020). The addition of zonulin to Gd-IgA1 showed better predictive performance than Gd-IgA1 alone in the diagnosis of both IgAN and IgAV-N, as illustrated by a significantly increased AUC (IgAN: 0.805 versus 0.708, P = .0021; IgAV-N: 0.886 versus 0.673, P < .001) and significant IDI (IgAN: IDI 0.136, P < .001; IgAV-N: IDI 0.281, P < .001). Elevated circulating zonulin levels were detected in both patients with IgAV-N and those with IgAN. Combined detection of circulating zonulin and Gd-IgA1 is recommended as a noninvasive diagnostic biomarker for IgAV-N and IgAN.
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影响因子：
6
作者：
Singh, Prashant;Silvester, Jocelyn;Lembo, Anthony
通讯作者：
Lembo, Anthony
IgA肾病的新风险基因座的发现暗示了与肠道病原体免疫有关的基因。
影响因子：
30.8
作者：
Kiryluk, Krzysztof;Li, Yifu;Scolari, Francesco;Sanna-Cherchi, Simone;Choi, Murim;Verbitsky, Miguel;Fasel, David;Lata, Sneh;Prakash, Sindhuri;Shapiro, Samantha;Fischman, Clara;Snyder, Holly J.;Appel, Gerald;Izzi, Claudia;Viola, Battista Fabio;Dallera, Nadia;Del Vecchio, Lucia;Barlassina, Cristina;Salvi, Erika;Bertinetto, Francesca Eleonora;Amoroso, Antonio;Savoldi, Silvana;Rocchietti, Marcella;Amore, Alessandro;Peruzzi, Licia;Coppo, Rosanna;Salvadori, Maurizio;Ravani, Pietro;Magistroni, Riccardo;Ghiggeri, Gian Marco;Caridi, Gianluca;Bodria, Monica;Lugani, Francesca;Allegri, Landino;Delsante, Marco;Maiorana, Mariarosa;Magnano, Andrea;Frasca, Giovanni;Boer, Emanuela;Boscutti, Giuliano;Ponticelli, Claudio;Mignani, Renzo;Marcantoni, Carmelita;Di Landro, Domenico;Santoro, Domenico;Pani, Antonello;Polci, Rosaria;Feriozzi, Sandro;Chicca, Silvana;Galliani, Marco;Gigante, Maddalena;Gesualdo, Loreto;Zamboli, Pasquale;Battaglia, Giovanni Giorgio;Garozzo, Maurizio;Maixnerova, Dita;Tesar, Vladimir;Eitner, Frank;Rauen, Thomas;Floege, Juergen;Kovacs, Tibor;Nagy, Judit;Mucha, Krzysztof;Paczek, Leszek;Zaniew, Marcin;Mizerska-Wasiak, Malgorzata;Roszkowska-Blaim, Maria;Pawlaczyk, Krzysztof;Gale, Daniel;Barratt, Jonathan;Thibaudin, Lise;Berthoux, Francois;Canaud, Guillaume;Boland, Anne;Metzger, Marie;Panzer, Ulf;Suzuki, Hitoshi;Goto, Shin;Narita, Ichiei;Caliskan, Yasar;Xie, Jingyuan;Hou, Ping;Chen, Nan;Zhang, Hong;Wyatt, Robert J.;Novak, Jan;Julian, Bruce A.;Feehally, John;Stengel, Benedicte;Cusi, Daniele;Lifton, Richard P.;Gharavi, Ali G.
通讯作者：
Gharavi, Ali G.
影响因子：
9
作者：
Gesualdo L;Di Leo V;Coppo R
通讯作者：
Coppo R
DOI：
10.1097/01.asn.0000013883.99976.22
发表时间：
2002-05-01
影响因子：
13.6
作者：
Pillebout, E;Thervet, E;Nochy, D
通讯作者：
Nochy, D
影响因子：
--
作者：
Liu, Li-jun;Li, Guang-tao;Zhang, Hong
通讯作者：
Zhang, Hong