The mucosal immune system and IgA nephropathy.

The mucosal immune system and IgA nephropathy.
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DOI:
10.1007/s00281-021-00871-y
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发表时间:
2021-10
影响因子:
9
通讯作者:
Coppo R
Coppo R
中科院分区:
医学1区
文献类型:
--
作者:
Gesualdo L;Di Leo V;Coppo R

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免疫球蛋白A肾病(IgAN)的确切发病机制尚不清楚,但新的证据证实了粘膜免疫的关键作用。本文综述了粘膜相关淋巴组织(MALT)在促进疾病发生中的关键作用,以及微生物区系、遗传因素、食物抗原、感染和粘膜免疫反应之间的关系。最后,我们评估了针对IgAN患者微生物和粘膜高反应性的潜在治疗方法。
The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly established but emerging evidence confirms a pivotal role for mucosal immunity. This review focuses on the key role of mucosa-associated lymphoid tissue (MALT) in promoting the onset of the disease, underlying the relationship among microbiota, genetic factors, food antigen, infections, and mucosal immune response. Finally, we evaluate potential therapies targeting microbes and mucosa hyperresponsiveness in IgAN patients.
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