Regional specialization of the tongue revealed by gustatory ganglion imaging.
Regional specialization of the tongue revealed by gustatory ganglion imaging.
复制标题
通过味觉神经节成像揭示了舌头的区域专业化。
DOI：
10.1016/j.isci.2022.105700
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发表时间：
2022-12-22
期刊：
影响因子：
5.8
通讯作者：
Macpherson, Lindsey J.
中科院分区：
文献类型：
--
作者：
Fowler, Bryan E.;Ye, Jiahao;Humayun, Saima;Lee, Hojoon;Macpherson, Lindsey J.
味觉信息由膝状体神经节神经元从舌前部传递，由颈静脉/结状体/岩神经节复合体的岩部神经元从舌后部传递。在这里，我们使用在小鼠体内钙成像比较编码的味觉信息在膝状体和岩神经节，在单神经元的分辨率。我们的数据支持的前/后专门化的味觉信息编码从舌头的神经节，岩神经元更敏感的鲜味或苦味和响应甜或咸的刺激比膝状体神经元。我们发现，鲜味（50 mM MPG + 1 mM IMP）促进唾液分泌时，适用于后，但不是前，舌头。这表明了哺乳动物舌头的功能性味觉图，其中前味觉通路和后味觉通路对特定的味觉品质有不同的响应，并且差异地调节味觉的下游生理功能，例如促进唾液分泌。膝状体和岩部味觉神经元对味觉刺激的反应不同岩部神经元更可能对苦味或鲜味刺激作出反应当将鲜味施加到舌后部而不是前部时，鲜味促进唾液分泌后味觉神经元可能整合到唾液分泌的不同回路中细胞神经科学;感觉神经科学
Gustatory information is relayed from the anterior tongue by geniculate ganglion neurons and from the posterior tongue by neurons of the petrosal portion of the jugular/nodose/petrosal ganglion complex. Here, we use in vivo calcium imaging in mice to compare the encoding of taste information in the geniculate and petrosal ganglia, at single-neuron resolution. Our data support an anterior/posterior specialization of taste information coding from the tongue to the ganglia, with petrosal neurons more responsive to umami or bitter and less responsive to sweet or salty stimuli than geniculate neurons. We found that umami (50 mM MPG + 1 mM IMP) promotes salivation when applied to the posterior, but not anterior, tongue. This suggests a functional taste map of the mammalian tongue where the anterior and posterior taste pathways are differentially responsive to specific taste qualities, and differentially regulate downstream physiological functions of taste, such as promoting salivation. Geniculate and petrosal gustatory neurons respond differentially to taste stimuli Petrosal neurons are more likely to respond to bitter or umami taste stimuli Umami promotes salivation when applied to the posterior, but not anterior, tongue Posterior gustatory neurons may integrate into distinct circuits for salivation Cellular neuroscience; Sensory neuroscience
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