Effects of Green Tea Catechins on Prostate Cancer Chemoprevention: The Role of the Gut Microbiome.
Effects of Green Tea Catechins on Prostate Cancer Chemoprevention: The Role of the Gut Microbiome.
复制标题
DOI：
10.3390/cancers14163988
复制
发表时间：
2022-08-18
期刊：
影响因子：
5.2
通讯作者：
Byrd DA
中科院分区：
文献类型：
--
作者：
Kumar NB;Hogue S;Pow-Sang J;Poch M;Manley BJ;Li R;Dhillon J;Yu A;Byrd DA
众所周知，绿茶的健康益处来自一种名为绿茶儿茶素(GTCS)的分子。GTC已被证明可以影响阻止前列腺癌(PCA)进展的分子途径，并可能对处于积极监测中的低风险前列腺癌患者特别有益。应用GTCS可能会为患者提供积极参与治疗的机会，并有助于防止癌症进展。重要的是，肠道(肠道微生物群)中数以万亿计的微生物代谢GTCS，使它们更容易被身体接触，发挥其健康影响。此外，肠道微生物群影响可能参与前列腺癌进展的其他多个过程，包括调节炎症、激素和其他已知/未知的途径。在这篇综述中，我们讨论(1)GTCS在预防PCa进展中的作用；(2)微生物组与PCa相关的现有证据；以及(3)利用微生物组识别可能预测GTCS改善反应的标志物，以加强临床决策。越来越多的证据支持绿茶儿茶素(GTCS)在前列腺癌(PCA)的化学预防中的作用，前列腺癌是男性癌症发病率和死亡率的主要原因。GTC包括(−)-表没食子儿茶素没食子酸酯，它可能调节与前列腺癌发生有关的分子通路。先前对GTCS的研究表明，它们在调节与前列腺癌发生有关的临床和生物标志物方面是生物可用、安全和有效的。GTCS可能对那些患有低度PCAS的人特别有利，通常通过主动监测(AS)进行仔细监测。尽管如建议的那样，它也有局限性，包括潜在的低估、资格差异以及男性在服用AS时报告的焦虑。使用GTCS对低级别PCAS进行二次化学预防可能有助于解决这些限制。口服时，肠道微生物群酶促GTC结构，改变其生物利用度、生物活性和毒性。除了异生代谢，肠道微生物群还具有多种可能参与前列腺癌进展的其他生理效应，包括调节炎症、激素和其他已知/未知的途径。因此，重要的是不仅要考虑GTCS和肠道微生物组在PCA化学预防中的独立作用，而且要考虑肠道微生物如何与个体对GTCS的反应有关，这反过来又可以增强临床决策。
Green tea is known for its health benefits deriving from molecules called green tea catechins (GTCs). GTCs have been demonstrated to influence molecular pathways to halt the progression of prostate cancer (PCa) and may be of particular benefit to men with low-risk PCa who are placed on active surveillance. Administering GTCs may provide patients an opportunity to be actively engaged in their treatment and help prevent cancer progression. Importantly, the trillions of microbes in the gut (the gut microbiome) metabolize GTCs, making them more accessible to the body to exert their health effects. Additionally, the gut microbiome influences multiple other processes likely involved in PCa progression, including regulating inflammation, hormones, and other known/unknown pathways. In this review, we discuss (1) the role of GTCs in preventing PCa progression; (2) current evidence for associations of the microbiome with PCa; and (3) utilizing the microbiome to identify markers that may predict improved response to GTCs to enhance clinical decision-making. Accumulating evidence supports green tea catechins (GTCs) in chemoprevention for prostate cancer (PCa), a leading cause of cancer morbidity and mortality among men. GTCs include (−)-epigallocatechin-3-gallate, which may modulate the molecular pathways implicated in prostate carcinogenesis. Prior studies of GTCs suggested that they are bioavailable, safe, and effective for modulating clinical and biological markers implicated in prostate carcinogenesis. GTCs may be of particular benefit to those with low-grade PCas typically managed with careful monitoring via active surveillance (AS). Though AS is recommended, it has limitations including potential under-grading, variations in eligibility, and anxiety reported by men while on AS. Secondary chemoprevention of low-grade PCas using GTCs may help address these limitations. When administrated orally, the gut microbiome enzymatically transforms GTC structure, altering its bioavailability, bioactivity, and toxicity. In addition to xenobiotic metabolism, the gut microbiome has multiple other physiological effects potentially involved in PCa progression, including regulating inflammation, hormones, and other known/unknown pathways. Therefore, it is important to consider not only the independent roles of GTCs and the gut microbiome in the context of PCa chemoprevention, but how gut microbes may relate to individual responses to GTCs, which, in turn, can enhance clinical decision-making.
登录
查看更多内容
影响因子：
3.8
作者：
Chow, H.-H. Sherry;Hakim, Iman A.;Alberts, David S.
通讯作者：
Alberts, David S.
影响因子：
4.6
作者：
Dwiyanto J;Hussain MH;Reidpath D;Ong KS;Qasim A;Lee SWH;Lee SM;Foo SC;Chong CW;Rahman S
通讯作者：
Rahman S
影响因子：
4.2
作者：
Adhami, VM;Ahmad, N;Mukhtar, H
通讯作者：
Mukhtar, H
影响因子：
4.6
作者：
Datta D;Aftabuddin M;Gupta DK;Raha S;Sen P
通讯作者：
Sen P
DOI：
10.1158/1078-0432.ccr-08-2332
发表时间：
2009-03-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Adhami VM;Siddiqui IA;Sarfaraz S;Khwaja SI;Hafeez BB;Ahmad N;Mukhtar H
通讯作者：
Mukhtar H