Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country.
Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country.
复制标题
DOI：
10.1038/s41598-021-82311-3
复制
发表时间：
2021-01-29
影响因子：
4.6
通讯作者：
Rahman S
中科院分区：
文献类型：
--
作者：
Dwiyanto J;Hussain MH;Reidpath D;Ong KS;Qasim A;Lee SWH;Lee SM;Foo SC;Chong CW;Rahman S
尚无研究调查种族对一个有着长期同居历史的多民族中等收入国家的影响。收集了 214 名马来西亚社区成员（46 名马来人、65 名华人、49 名印度人和 54 名贾昆人）的粪便样本。使用 16S 扩增子测序对参与者的肠道微生物群进行了研究。种族对参与者的影响最大（PERMANOVA Pseudo-F = 4.24，R2 = 0.06，p = 0.001）。值得注意的是，即使在控制了所有人口统计、饮食因素和其他与肠道微生物组显着相关的协变量后，种族对肠道微生物群的影响仍然存在（PERMANOVA Pseudo-F = 1.67，R2 = 0.02，p = 0.002）。我们的结果表明，生活方式、饮食和未表征的差异共同驱动了不同种族之间肠道微生物群的变化，使种族成为同一社区不同种族之间已确定和未确定的生活方式和饮食变化的可靠代表。
No studies have investigated the influence of ethnicity in a multi-ethnic middle-income country with a long-standing history of co-habitation. Stool samples from 214 Malaysian community members (46 Malay, 65 Chinese, 49 Indian, and 54 Jakun) were collected. The gut microbiota of the participants was investigated using 16S amplicon sequencing. Ethnicity exhibited the largest effect size across participants (PERMANOVA Pseudo-F = 4.24, R2 = 0.06, p = 0.001). Notably, the influence of ethnicity on the gut microbiota was retained even after controlling for all demographic, dietary factors and other covariates which were significantly associated with the gut microbiome (PERMANOVA Pseudo-F = 1.67, R2 = 0.02, p = 0.002). Our result suggested that lifestyle, dietary, and uncharacterized differences collectively drive the gut microbiota variation across ethnicity, making ethnicity a reliable proxy for both identified and unidentified lifestyle and dietary variation across ethnic groups from the same community.
登录
查看更多内容
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
46.9
作者：
Costea, Paul I.;Zeller, Georg;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
9.8
作者：
Gevers D;Knight R;Petrosino JF;Huang K;McGuire AL;Birren BW;Nelson KE;White O;Methé BA;Huttenhower C
通讯作者：
Huttenhower C
影响因子：
3.7
作者：
Jain A;Li XH;Chen WN
通讯作者：
Chen WN